Robert F. Garry

https://www.theguardian.com/commentisfree/2020/jun/09/conspiracies-covid-19-lab-false-pandemic?CMP=share_bt n_tw "Writing in the peer-reviewed journal Nature Medicine, researchers strongly refuted the idea that the code had been purposefully manipulated.

Slack / Private Message Drop, p.67 · original PDF · in context

The CoVs from the frothy pangolins are pretty diverse - multiple introductions, long time evolving or both?

Slack / Private Message Drop, p.74 · original PDF · in context

IOWS what is the Proximal Origin of Pangolin-SARS?

Slack / Private Message Drop, p.74 · original PDF · in context

Lots ofhydroxychloroquine was poured into COVID patients.

Slack / Private Message Drop, p.90 · original PDF · in context

but unfortunately it's not what they doinghttps://www.forbes.com/sites/brucejapsen/2020/06/02/fauci-modernas-phase-3-covid-19-vaccine-trial-will-include-30000-young-and-old-individuals/#316e15174f75

Slack / Private Message Drop, p.104 · original PDF · in context

Probably not, but if they are giving them the proper advice - mask upsocial distance etc - you should have VERY FEW infections in the 30,000.

Slack / Private Message Drop, p.105 · original PDF · in context

Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.

Slack / Private Message Drop, p.105 · original PDF · in context

https://www.msn.com/en-us/health/medical/close-relatives-of-the-novel-coronavirus-may-have-circulated-in-bats-for-decades-before-jumping-to-humans/ar-BB17gNfN This piece is also likely to show up in _Scientific American_ according to the reporter, who works both for the paper and _SciAm_.

Slack / Private Message Drop, p.114 · original PDF · in context

BTW - Proximal Origins is at 4.87m accesses - seems destined to cross 5m in a few weeks, which is actually quite remarkable.

Slack / Private Message Drop, p.117 · original PDF · in context

Rather, our aim was to carefully examine in a balanced and unbiased manner the evidence for and against a number of possible probable scenarios for the proximal origins of SARS-CoV-2.* But more importantly this reviewer feels, and we agree, that the Perspective would quickly become outdated when more scientific data are published (for example on potential reservoir hosts).*Of course, it is likely that more scientific data will swing the balance in favor of one hypothesis over another.

Slack / Private Message Drop, p.121 · original PDF · in context

What I can't really imagine is the conversations Lauer had - with say the CIA - to lead him to ask Daszak that series of questions.

Slack / Private Message Drop, p.140 · original PDF · in context

I'm pretty sure he's going to try to do this - esp as the poll numbers either stay the same or more likely move a bit more to Biden/Harris - this is literally who he is and nothing else other than getting re-elected matters in the least -I'm also pretty sure this is going to be a line in the sand for not only the vaccine manufacturers but the FDA, NIH, even the Warp Speed commandos themselves - be ready to speak out.

Slack / Private Message Drop, p.154 · original PDF · in context

https://www.thedailybeast.com/steve-bannon-linked-groups-push-study-claiming-china-manufactured-covid?ref=scr oll - it's a start, but a note to Angie that furin sites are not YET found in other bat-CoVs.

Slack / Private Message Drop, p.172 · original PDF · in context

The pangolin CoVs (that Alina seems focused on) and other BtCoVs were sufficient for the Proximal Origins analysis.

Slack / Private Message Drop, p.178 · original PDF · in context

```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV.

Slack / Private Message Drop, p.185 · original PDF · in context

Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally.

Slack / Private Message Drop, p.186 · original PDF · in context

https://pubmed.ncbi.nlm.nih.gov/32869021/ Furin site is important

Slack / Private Message Drop, p.189 · original PDF · in context

What are we supposed to do - spend a couple of billion and make vaccines to these viruses?

Slack / Private Message Drop, p.209 · original PDF · in context

I also think there are likely special patients that exist that spread especially well and that very high virus load is a major discriminator btwn the standard and special patients.

Slack / Private Message Drop, p.212 · original PDF · in context

That being said we're about to put something up on virological - might run it by here first - showing serorxty to SARS-CoV-2, N, Sand RBD in samples from SL back to 2008.

Slack / Private Message Drop, p.214 · original PDF · in context

Similar results were obtained in comparing the reactivities of N to S.Differences in reactivities to N and S or RBD are expected and similar to differential reactivities observed for LASVnucleoprotein versus glycoprotein (Heinrich et al., 2020).The distribution of the positive samples over the time of collection appears to be non-random.

Slack / Private Message Drop, p.214 · original PDF · in context

Probably the same WHO 'insiders' who insisted for months that SARS-CoV-2 was mostly spread by fomites [just wash your hands and use a pencil to touch elevator buttons], was NOT airborne, forgot to advise about social distancing/isolating cases and discouraged mask use.

Slack / Private Message Drop, p.255 · original PDF · in context

At least 45 and associatedclowns are on the way out....

Slack / Private Message Drop, p.258 · original PDF · in context

What's not known [here's the speculation] is if the NTD of SARS-CoV2 (where the 69/70 deletion is actually part of a receptor binding domain forsialic acid or other molecule.

Slack / Private Message Drop, p.261 · original PDF · in context

*I do agree that Proximal Origins 2 should happen sooner than later - just not certain of the best approach or approaches -we seem to have attracted some attention with PO1 so a sequel - given the persistence of the unnatural crowd would likely be noticed. @Andrew Rambaut has made a good start.

Slack / Private Message Drop, p.268 · original PDF · in context

*project-wuhan_pangolin* - Jul 27th View in channel *Eddie Holmes* [9:50 PM] I'm not sure what I would conclude except that it is completely inappropriate to discuss the thoughts of the editors atNature.

Slack / Private Message Drop, p.279 · original PDF · in context

The other news - which is obviously strictly confidential - is that someone in China (Tong?) has apparently obtained a MERS-like virus from a pangolin.

Slack / Private Message Drop, p.280 · original PDF · in context

Yes - the ringer was the furin cleavage site which threw everyone off since on first glance it appears so striking.

Slack / Private Message Drop, p.280 · original PDF · in context

FromHarvard2The BigHouse <harvard2t>Subject*Are you aware you're participating in a war crime?*DateMar 21stSo I'm sure your handlers have assured you that the money can't be traced, but one of the most astonishing things Ilearned at NSA was how incredibly easy it is to trace financial transactions that aren't supposed to be traceable.

Slack / Private Message Drop, p.294 · original PDF · in context

Yeah - I suspected that the DRASTIC goons might not appreciate getting the friendly doxxing.

Slack / Private Message Drop, p.294 · original PDF · in context

I suspect this Australian organization is involved somehow: https://pangolinassociates.com/

Slack / Private Message Drop, p.303 · original PDF · in context

Proximal Origins? https://thehill.com/homenews/news/529300-israels-ex-space-boss-trump-was-on-the-verge-of-rev ealing-extraterrestrials

Slack / Private Message Drop, p.308 · original PDF · in context

The most likely emails of ours that could *possibly* be FOIAed are the ones with .gov email recipients.

Slack / Private Message Drop, p.316 · original PDF · in context

Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.

Slack / Private Message Drop, p.318 · original PDF · in context

@Andrew Rambaut Yeah the A in the ancestral threw me off a bit, but - that region between the FCS and the S2' cleavage site it generally thought to be clipped out - the S2' cleavage exposes what is likely the fusion peptide (there may be other FPs).

Slack / Private Message Drop, p.319 · original PDF · in context

What's dangerous is that the Lab origin crowd will make it difficult to actually going out and do the field work find/characterize the wild covs that we must characterize to prevent SC3 [or a pandemic nonsarbecovirus] from doing what SC2 is doing.

Slack / Private Message Drop, p.324 · original PDF · in context

I think the people who have been doing the monoclonal antibody work need to start sharing their epitope data.

Slack / Private Message Drop, p.331 · original PDF · in context

Knock out a few and you might not kill vaccine effectiveness altogether but effectiveness could take a pretty big hit.

Slack / Private Message Drop, p.331 · original PDF · in context

Another problem is that in vitro studies might rapidly identify a problem if the vaccinee plasma has reduced ability toneutralize.

Slack / Private Message Drop, p.331 · original PDF · in context

Knocking out two neutralizing epitope would not likely be a good thing for vaccine efficacy.

Slack / Private Message Drop, p.331 · original PDF · in context

The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant.

Slack / Private Message Drop, p.338 · original PDF · in context

The other elephant mutations outside RBD including the dels in the NTD and the P681H near the FCS could indeed be enabling, enhancing replication in their own right or perhaps they are also immune escapes.

Slack / Private Message Drop, p.341 · original PDF · in context

I think this is all relevant to PO2 - it's pretty clear that the changes in SC2 493 and 501 or SC1 479 and 487 enabledspecies jumps - per PO1 there are bat sarbecovs that have an SC2 N501 and we know these infect human cells.We know enough about the epitopes and MAb binding and escape to back up Andrew's point on virological that immune escape is driving the changes in the elephants - the problem happens when immune escape creates variants that are more transmissible or heaven forbid are vaccine resistant.

Slack / Private Message Drop, p.341 · original PDF · in context

Covs have other viroporins (E protein) that are virion associated, but NSP6 is likely remodeling cell membranes insome way to benefit virus replication.

Slack / Private Message Drop, p.342 · original PDF · in context

Right on cue - nonSpike protein nsp6 @Andrew Rambaut as predicted - the deletion is in a large external loop - very likely to impact nsp6 function or regulation!

Slack / Private Message Drop, p.342 · original PDF · in context

The lions also have mutations associated with Doug,

Slack / Private Message Drop, p.347 · original PDF · in context

@Eddie Holmes Is the Simplot a GD pangolin?

Slack / Private Message Drop, p.348 · original PDF · in context

Seems like it should score higher than RaTG13 in part of the RBD.

Slack / Private Message Drop, p.348 · original PDF · in context

I don't think James is in the Lab Origins camp.

Slack / Private Message Drop, p.357 · original PDF · in context

For example the Lab leak hypothesis paper starts out: "Nevertheless, I think it's worth offering some historical context for our yearlong medical nightmare.

Slack / Private Message Drop, p.358 · original PDF · in context

https://www.globenewswire.com/news-release/2021/01/08/2155442/0/en/An-In-Vitro-Study-Sh[...]ation-Associatedwith-Rapid-Transmission.html?source=email Good to see but unfortunately Nelly is not the most concerning....

Slack / Private Message Drop, p.368 · original PDF · in context

QTQTN is present in GD pangolin and RaTG13, but not SC1.

Slack / Private Message Drop, p.370 · original PDF · in context

Ahhh yes - the Queen Victoria hotel is pretty special and you can take a side trip to the Ziika forest.

Slack / Private Message Drop, p.370 · original PDF · in context

Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.

Slack / Private Message Drop, p.380 · original PDF · in context

The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.

Slack / Private Message Drop, p.380 · original PDF · in context

The genetic structure of SARSnCoVn2 does not rule out a laboratory originSARSnCOVn2 chimeric structure and furin cleavage site might be the result of genetic manipulationRossana Segreto Yuri Deigin

Slack / Private Message Drop, p.402 · original PDF · in context

This means getting you ~flu~ CoV vaccine each year or maybe even every 6 months.

Slack / Private Message Drop, p.415 · original PDF · in context

Agree Nat Micro likely landing spot - I also agree Fig 2 is interesting and appreciate the long region of similarity toRmYN02 and RaTG13 plus the variation on the indel theme Fig 3c.

Slack / Private Message Drop, p.425 · original PDF · in context

But gotta admit they are scoring points: https://www.newsweek.com/beijing-must-come-clean-about-covid-19-origins-opinion-1563524

Slack / Private Message Drop, p.435 · original PDF · in context

@Andrew Rambaut Agree with this - optimal cleavage might vary depending on multiple factors - cleave in the wrong tissue or wrong time not good. - An optimal cleavage site is RRXRR.

Slack / Private Message Drop, p.441 · original PDF · in context

Yes a bigger study - these two likely others are probably already looking at structures of the new variants, but yours will really get their blood boiling.CDC declined to come and do any contact tracing, but did offer up some advice for quarantining the patient.

Slack / Private Message Drop, p.449 · original PDF · in context

In a significant change from a year ago, a growing number of top experts - including (ordered alphabetically by last name) Drs Francois Balloux, Ralph S Baric, Trevor Bedford, Jesse Bloom, Bruno Canard, Etienne Decroly, Richard H Ebright, Michael B Eisen, Gareth Jones, Filippa Lentzos, Michael Z Lin, Marc Lipsitch, Stuart A Newman, Rasmus Nielsen, Megan J Palmer, Nikolai Petrovsky, Angela Rasmussen and David A Relman - have stated publicly (several in early 2020) that a lab leak remains a plausible scientific hypothesis to be investigated, regardless of how likely or unlikely.

Slack / Private Message Drop, p.489 · original PDF · in context

I think it's the problem that spike is wild-type - not stabilized as in the mRNA vaccines - am I right about this?

Slack / Private Message Drop, p.496 · original PDF · in context

I still think that the most likely thing that Doug and the Q613H/R mutants are doing is adjusting the charge there andloosening up the trimer, but no reason that they couldn't be generating a new or better cleavage site as well.

Slack / Private Message Drop, p.502 · original PDF · in context

Relevant discussion after you left on the EBOV vaccine - seems that protection is rather short-livedtoo which explains the vaccinee infections, re-infections or recrudescence.

Slack / Private Message Drop, p.521 · original PDF · in context

I think a scenario of a yearly vaccination with constant updating [stabilized spike of course] is the most likely outcome - and yes it's not the flu so there will a a death toll, so not pretty.

Slack / Private Message Drop, p.532 · original PDF · in context

Actually, he is precisely alleging it came from the WIV.

Slack / Private Message Drop, p.535 · original PDF · in context

@Kristian Andersen The T372A change is in the CTD, it does not likely interact with ACE2 at any level so I don't think it's in the RBD per se.

Slack / Private Message Drop, p.540 · original PDF · in context

The intermediate hosts/reservoirs, might grow virus to higher levels (like say civets for SC1), but probably varies a lot from animal to animal like humans .

Slack / Private Message Drop, p.575 · original PDF · in context

Sicksnotty nose pangolins might have higher loads for their viruses, too.

Slack / Private Message Drop, p.575 · original PDF · in context

I agree with most all of this - does that make me a socialist? https://www.wsws.org/en/articles/2021/03/06/wuha-m06.html

Slack / Private Message Drop, p.578 · original PDF · in context

WashPost spinning here. i'm guessing [hoping] White house are smart enough to figure this out - maybe with a little help from Kristian... [shared file(s): Opinion I The Biden administration conf...Wuhan lab claims - The Washington Post.pdf]

Slack / Private Message Drop, p.581 · original PDF · in context

Then there is the whole lineage A and B = the animals in the Huanan market are lineage B, so how did lineage A get started?

Slack / Private Message Drop, p.598 · original PDF · in context

Is it so shocking that so many of the lab origins proponents canbe linked to the Murdoch press?

Slack / Private Message Drop, p.617 · original PDF · in context

NTD is the receptor binding domain of many CoVs.

Slack / Private Message Drop, p.619 · original PDF · in context

The lineage A and B is a big clue - argues against lab leak - otherwise the nefarious Shi and her henchmen seedednot one but 2 markets with two lineages to cover their tracks?

Slack / Private Message Drop, p.626 · original PDF · in context

I think that the onus on the lab leak proponents shouldbe to focus on specifics as to what they feel was lacking in the report.2.

Slack / Private Message Drop, p.648 · original PDF · in context

The extensive section of the negative results in all the animals tested will probably get the most attention by Lab leak proponents.

Slack / Private Message Drop, p.648 · original PDF · in context

Huanan Market and the Other market data are key.

Slack / Private Message Drop, p.659 · original PDF · in context

Although the team has concluded that a laboratory leak is the least likely hypothesis, this requires further investigation, potentially with additional missions involving specialist experts, which I am ready to deploy.We will keep you informed as plans progress, and as always, we very much welcome your input.

Slack / Private Message Drop, p.660 · original PDF · in context

DoS member is either Asher [they're genetically engineering Super-Soldiers] or Pottinger [a few ppl maybe had ILI atWIV in 2019].

Slack / Private Message Drop, p.674 · original PDF · in context

@Kristian Andersen Is this what David - Captain China - Asher was referring to when he described Pangolins and Bats mating?

Slack / Private Message Drop, p.678 · original PDF · in context

I think that these same Republican people if they a`re really serious should demand release of the intel about the supposed sick people at WIV in November and the covert military activities, including animal experiments, conducted for the CCP army.

Slack / Private Message Drop, p.714 · original PDF · in context

And, what IF - anything being possible - we also get a whistleblower account that says that the WIV was also exploring not only with putting in the FCS, but using a 12 base out-of-frame insertion that adds a proline - yes aproline - as well as creating o-linked glycosylation sites?

Slack / Private Message Drop, p.717 · original PDF · in context

Yes - they are all aggrieved parties - especially Alina.

Slack / Private Message Drop, p.747 · original PDF · in context

Sucks - US has literally more vaccine than they know what to do with, but few Republicans want to take it because -who knows why? - Fauci is a bad man?

Slack / Private Message Drop, p.777 · original PDF · in context

The Nature paper was rightly focused on SARS-CoV-2.Concocting some sort of a narrative that they were covering up the provenance of RaTG13 and other viruses for the mine, while previously publishing Ge et al. etc seems a bit over-blown.And the scant info in the WHO report about a possible lab accident was just a series of declarations of negative results without provision of any primary data: if a student came to you with a research conclusion, wouldn't you askto see the data, the methods and the controls?

Slack / Private Message Drop, p.793 · original PDF · in context

Ian has gone over to the the Lab Leakers (aka FOMOs) .

Slack / Private Message Drop, p.795 · original PDF · in context

https://elpais.com/ciencia/2021-05-13/un-grupo-de-destacados-cientificos-pide-una-autentica-investigacion-del-origen-de-la-pandemia.html "Epidemiologist Ian Lipkin , a world authority on emerging pathogens, was another of five experts who in March 2020 pointed to a natural origin of the coronavirus as the most likely hypothesis.

Slack / Private Message Drop, p.796 · original PDF · in context

@Eddie Holmes Yes - he is off of social media.

Slack / Private Message Drop, p.809 · original PDF · in context

Going back to JB's intentional release statement - does he really believe that someone at WIV or another lab in Wuhan released a bioweapon on their own people?

Slack / Private Message Drop, p.815 · original PDF · in context

https://reason.com/2021/05/13/is-this-a-covid-19-smoking-gun-or-is-it-a-damp-squib/ Furin cleavage site.

Slack / Private Message Drop, p.815 · original PDF · in context

https:/Awww.nationalreview.com/news/biosafety-expert-explains-why-faucis-nih-gain-of-function-testimony-was-dem onstrably-false/

Slack / Private Message Drop, p.820 · original PDF · in context

Questions - 1. safe to saw the decreases are vaccine related or not? 2.

Slack / Private Message Drop, p.823 · original PDF · in context

Agree, the whole thing about not using the best vaccines likely becomes key.

Slack / Private Message Drop, p.824 · original PDF · in context

Yes - the stigma issue was well-discussed and vaccination might be key.

Slack / Private Message Drop, p.840 · original PDF · in context

OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).

Slack / Private Message Drop, p.841 · original PDF · in context

But whipping up this hysteria about an accidental lab leak that Relman says the might not have even known???

Slack / Private Message Drop, p.847 · original PDF · in context

New reporting but fucking Fox news done good (sorta) - very hard to believe but a *highly recommended read* on David -Captain China - Asher and the probe that Biden cancelled - also mentions Steven Quay and his Bayesian analysis - calls it crap. https://www.msn.com/en-us/news/politics/former-state-department-official-reveals-p[...]cerns-with-wuhan-covid-19-origin/ar-AAKpGpq?ocid=BingNewsSearch

Slack / Private Message Drop, p.876 · original PDF · in context

Clearly Relman has only one thing on his agenda: [shared file(s): Lab leaks happen, and not just in China.

Slack / Private Message Drop, p.905 · original PDF · in context

Yes - indeed - Denise Chow one of two reporters allowed into WIV has no doubt that the LL is pure crap - she got pushed to the back and my statement seems to have been selectively edited - sure investigate but only to put the bSto rest.

Slack / Private Message Drop, p.921 · original PDF · in context

Worobey) that have spoken outin favor of Lab Leak.

Slack / Private Message Drop, p.933 · original PDF · in context

and this just in from JB to the email chain (foias R' us) By the way, I just wanted to add one last piece of information prior to the meeting that might be relevant.

Slack / Private Message Drop, p.948 · original PDF · in context

Pretty intense actually ----but I believe that the two factors that flipped the thinking were the mutational pattern in the RBD showing a likely natural pathway and the plethora of natural FCS and high variability at the S1/S2 junction. [shared file(s): image.png]

Slack / Private Message Drop, p.985 · original PDF · in context

With SC2 we'll have all the same genomes except the intermediate host (and I think a good assumption that there is one).

Slack / Private Message Drop, p.1002 · original PDF · in context

Also well documented that the Hubei Province Districts Centres for Disease Control and Prevention (May-Dec 2019)was moving into new building near the Huanan market in 2019 - they probably got themselves some new PCRmachines then.

Slack / Private Message Drop, p.1009 · original PDF · in context

Does not mean it can't involve a mRNA -Yuri even found some examples in the literature - just means for me it's much more infrequent.

Slack / Private Message Drop, p.1013 · original PDF · in context

In all seriousness though we probably do need to let someone like the CIA or the White House know about Q61-70.

Slack / Private Message Drop, p.1020 · original PDF · in context

Please let me know, and thank you for your time,MaiaMaia HibbettAssociate Politics Editor, The Intercept

Slack / Private Message Drop, p.1051 · original PDF · in context

Ialsomentioned that he should probably acknowledge the Feb 1 teleconference or else the Lab Leak crowd would accuse him of being part of the conspiracy/cover-up.

Slack / Private Message Drop, p.1076 · original PDF · in context

What happened is that WE threw out a bunch of scenarios - many people on the call trashed us for even considering Lab Leak.

Slack / Private Message Drop, p.1111 · original PDF · in context

no - I think you are special @Kristian Andersen

Slack / Private Message Drop, p.1113 · original PDF · in context

@Kristian Andersen et al - you might want to go over Worobey2022 one mo' time.

Slack / Private Message Drop, p.1115 · original PDF · in context