Chat message

Slack / Private Message Drop, p.318 [SLACK_000532] · slack_pm:msg:03343

Date: 2020-12-16 04:33
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.

Extracted statements

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Statement	Grade	Attribution	Stance
Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-16 04:12 Robert F. Garry open

If the change in the FCS makes it somehow better able to infect the upper airways this could impact spread. Mightbe reflected in lower Ct values in nasal swabs.
2020-12-16 04:33 Robert F. Garry

Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.
2020-12-16 04:41 Andrew Rambaut open

Yes - I am really convinced it is spreading because of these mutations not despite. And I am usually very cautious. Iam keeping my eye on a lineage with N501Y and none of the other mutations that is also spreading in the UK.

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