Chat message

Slack / Private Message Drop, p.841 [SLACK_001055] · slack_pm:msg:08757

Date: 2021-05-19 15:17
Type: chat message · slack
mentioned: Edward C. Holmes
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Eddie Holmes • Intermediate hosts also instructive. Intermediate host of of HKU1 and HL63 like SC2 is not known. MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established. For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven. SC1 civets obviously can infected in wildlife trade, but could be other spillover hosts and the reservoir may be another animal. OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Intermediate host of of HKU1 and HL63 like SC2 is not known.	own voice, substantive	speaker_own	asserts
MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established.	own voice, substantive	speaker_own	asserts
For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven.	own voice, substantive	speaker_own	asserts
OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).	needs context	uncertain explicit hedge	questions

Statement

Grade

Attribution

Stance

Intermediate host of of HKU1 and HL63 like SC2 is not known.

own voice, substantive

speaker_own

asserts

MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established.

own voice, substantive

speaker_own

asserts

For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven.

own voice, substantive

speaker_own

asserts

OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).

needs context

uncertain explicit hedge

questions

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-05-19 14:48 Edward C. Holmes open

@Eddie Holmes Yes, no one would engineer that RBD so it has to be natural. And if that's natural so is the FCS. That then must mean they had a virus very close to SC2 at WIV. But if had worked on and sequenced such a virus -which would have been so interesting - why is there no record of it in their data or a paper? If both such a virus and RaTG13 had come out of a mine in Yunnan would they have only published RaTG13?
2021-05-19 14:53 Andrew Rambaut open

Look forward to it! It was an interesting experience getting 3 competing groups to all work together and just publish one good paper!
2021-05-19 15:00 Robert F. Garry open

Well done - if you don't mind I'll mention that very thing [in a nice way].
2021-05-19 15:09 Robert F. Garry open

@Eddie Holmes SC1 in Foshan (7.2M ppl) farmers, market vendors, and chefs). Agree that Eddie HKU1 emerging in Shenzhen (13M ppl) is instructive.
2021-05-19 15:17 Robert F. Garry

@Eddie Holmes • Intermediate hosts also instructive. Intermediate host of of HKU1 and HL63 like SC2 is not known. MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established. For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven. SC1 civets obviously can infected in wildlife trade, but could be other spillover hosts and the reservoir may be another animal. OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).
2021-05-19 15:23 Kristian G. Andersen open

@Eddie Holmes I don't really think camels can be considered an "intermediate" host for MERS - seems more to me that MERS is causing an epizootic in camels, so it's pretty much a camel virus by now.
2021-05-19 15:23 Robert F. Garry open

@Eddie Holmes Spillovers are rare. Domesticated animals a key at least for Covs- probably by serving to amplify the virus in close quarters. Pigs get other CoVs - PEDV and SADS-CoV - that are likely direct spillovers from bats. Something about the big cities makes the spillover stick. Could be same thing this time humans living in closequarters able to initiate transmission chains. This happened in West Africa Ebola. The reason why no very large Ebola outbreaks in Middle Africa is population density (we might have a paper on that).
2021-05-19 15:26 Robert F. Garry open

@Eddie Holmes Good point - but that makes the distinction btwn MERS and the rest of the human CoVs all that stronger.
2021-05-19 15:31 Robert F. Garry open

@Eddie Holmes So, question: is SC1 an epizootic in civets? Hard to argue there's definite proof of that but maybe i'm missing something.

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