Chat message

Slack / Private Message Drop, p.1002 [SLACK_001216] · slack_pm:msg:10458

Date: 2021-09-21 16:02
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features Natural origin / zoonotic spillover

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Some of the most valuable info is going to come from sorting out the parallels btwn SC1 and SC2. It's ironic that two KEY pieces surfaced in the past few weeks- the hubel civet viruses and the BANAL bat viruses. With SC1 and a littleelbow grease you'll see the adaptions from bat to civet to human and then human to human. With SC2 we'll have all the same genomes except the intermediate host (and I think a good assumption that there is one). In both SC1 andSC2 you've got highly similar N-glycan changes in the NTD followed by very similar and specific RBD changes. It's possible the NTD changes opened the door for the RBD changes. Put the FCS aside - nobody did these previouslyundiagnosed NTD and RBD changes by design.

Extracted statements

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Statement	Grade	Attribution	Stance
With SC2 we'll have all the same genomes except the intermediate host (and I think a good assumption that there is one).	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

With SC2 we'll have all the same genomes except the intermediate host (and I think a good assumption that there is one).

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-09-21 15:25 Kristian G. Andersen open

Getting Linfa's take on this would be great - he's on the grant too and he also hasn't mentioned anything about this.
2021-09-21 15:27 Edward C. Holmes open

I'll get onto it. I'm also going to have to chat to the intelligence folk.
2021-09-21 16:02 Robert F. Garry

Some of the most valuable info is going to come from sorting out the parallels btwn SC1 and SC2. It's ironic that two KEY pieces surfaced in the past few weeks- the hubel civet viruses and the BANAL bat viruses. With SC1 and a littleelbow grease you'll see the adaptions from bat to civet to human and then human to human. With SC2 we'll have all the same genomes except the intermediate host (and I think a good assumption that there is one). In both SC1 andSC2 you've got highly similar N-glycan changes in the NTD followed by very similar and specific RBD changes. It's possible the NTD changes opened the door for the RBD changes. Put the FCS aside - nobody did these previouslyundiagnosed NTD and RBD changes by design.
2021-09-21 16:05 Kristian G. Andersen open

Yup, all important points Bob. As for the glycans - do you have the coordinates?
2021-09-21 16:06 Kristian G. Andersen open

I'm done with my Zoom calls so I'll focus on this for the rest of the day/night.
2021-09-21 16:24 Robert F. Garry open

For SC2 to laos bat 52 its N 30, 74 and 370.
2021-09-21 16:25 Robert F. Garry open

SC1 coming

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