Professor, Tulane University
| Authored | 3,293 |
| Substantive (25+ words) | 1,388 |
| Threads posted in | 1,032 |
| Distinct active days | 437 |
| Words authored | 122,685 |
| Received (incl. group broadcast) | 8,441 |
Received counts include every message sent to a channel this person belonged to. That measures presence, not participation.
744 sentences were extracted and attributed to this person. Most are not their own opinion. Reporting the total as “744 statements” would misrepresent them.
| Person | Medium | Msgs | Span |
|---|---|---|---|
| Kristian G. Andersen | slack | 6,849 | 2020-04-30 – 2023-06-28 |
| Edward C. Holmes | slack | 6,278 | 2020-04-30 – 2022-06-02 |
| Andrew Rambaut | slack | 5,191 | 2020-04-30 – 2022-06-02 |
| Kristian G. Andersen M | 1 | 2020-03-06 – 2020-03-06 | |
| Uslackbot | slack | 1 | 2021-05-14 – 2021-05-14 |
Showing: own voice, substantive needs context quoted / not their view all
oppps...."One *Nature Medicine paper* further indicated that the pandemic virus shows no signs of having been engineered by scientists, another contention of conspiracy theorists.
Slack / Private Message Drop, p.6 · original PDF · in context
And Kristian welcome to this rather exclusive "club." Hooper write; "But for Kristian Andersen to claim that the workby his colleagues and himself "rules out" the lab origin theory, and for Josie Golding to claim that it "end[s] any speculation" along such lines, is clearly premature and inaccurate.
Slack / Private Message Drop, p.11 · original PDF · in context
I believe that as itstands at present, the lab origin hypothesis is at least as plausible a hypothesis as that of origin from Wuhanbushmeat."
Slack / Private Message Drop, p.11 · original PDF · in context
You are a scientist and not a politician but you looked like a very dull politician who has no idea what he was talking about.
Slack / Private Message Drop, p.20 · original PDF · in context
You have failed as a politician and you have tried to politicize this important and vital issue but you have failed successfully as a scientist as well. *Blame China for not telling the world everything, ganging with the WHO, and hoarding PPEs instead of blaming the President.*If bat corona research is so important, which I totally disagree with you, why then at least say that it is important but China should NOT be the one to conduct such a dangerous research because obviously they have no idea about what they are doing and the results are so obvious.
Slack / Private Message Drop, p.20 · original PDF · in context
"My first look at the virus suggested that the pattern of distribution of sequence variation across the genome looked natural, but that may too broad brush." ProfBill has a new long read on Virological on this topic - synonymous mutations look very normal from bat to pangolin.
Slack / Private Message Drop, p.24 · original PDF · in context
@Eddie Holmes The remarkable thing about this little rant is that he seems to be implying that he was running the two PCR tests POTUS mentions as well as the BioFire HIMSELF.
Slack / Private Message Drop, p.28 · original PDF · in context
And with that - Kristian will very much appreciate the fact for my own mental health - I'm getting back to work onother things.
Slack / Private Message Drop, p.28 · original PDF · in context
"_However, since we observed all notable SARS-CoV-2 features, including the optimized RBD and polybasic cleavage site, in related coronaviruses in nature, we do not believe that *any* type of laboratory-based scenario isplausible."_
Slack / Private Message Drop, p.29 · original PDF · in context
I'm the BBC Correspondent based in Beijing... and have, of course, been covering the outbreakof sars-covid-2 here in China since early this year.
Slack / Private Message Drop, p.33 · original PDF · in context
Ihave a few questions on which I would value your input related to the recent paper that you co-authored in Nature Medicine.In the first instance I was hoping for a brief background chat over the phone, but alternatively, if easier we couldconverse over email.
Slack / Private Message Drop, p.33 · original PDF · in context
It's obvious, but the only bits I'm really interested in are the RBD and the cleavage site of the progenitor of SARS-CoV-2.
Slack / Private Message Drop, p.34 · original PDF · in context
"CGTN is a propaganda organ for the Chinese government" Lot of that going around these days - I wonder if the 9 foot green spacewomen would be able to discern the difference with Fox Spews or any other Murdoch related garbage.
Slack / Private Message Drop, p.37 · original PDF · in context
The 12base pair insertion is - as ProfBill pointed out - out of frame.
Slack / Private Message Drop, p.38 · original PDF · in context
Then there are the Mikovitses of the world who occupy their own special place.
Slack / Private Message Drop, p.43 · original PDF · in context
What has happened is that case numbers have dropped in Italy, no doubt because of "some of the most rigidlockdown restrictions introduced anywhere on the continent.""The swabs that were performed over the last 10 days showed a viral load in quantitative terms that was absolutelyinfinitesimal compared to the ones carried out a month or two months ago." This is almost certainly due to the fact that in the early days of the outbreak in Italy a larger percentage of very sick individuals we tested by the qPCRS.
Slack / Private Message Drop, p.47 · original PDF · in context
Here's one example:https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30232-2/fulltext"The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes."Anecdotes are not science and shouldn't drive public health policy - particularly during a pandemic.
Slack / Private Message Drop, p.47 · original PDF · in context
That would help toexplain the otherwise puzzling extreme infectivity of Covid-19 and hence also help to explain the social epidemiologyof its spread." *Love, art thou sweet? then bitter death must be: Love, thou art bitter; sweet is death to me.
Slack / Private Message Drop, p.53 · original PDF · in context
Just a reminder that HKU1 and OC43 spikes also have big predicted mucin-like domains in "place" of the ACE-2 RBD.
Slack / Private Message Drop, p.55 · original PDF · in context
Sorry - messed up the links above - the elife paper does a considerable amt of arm waving over an 8 amino acid homology -the furin site - but "interesting" that the furin site in both SARS-CoV-2 and ENaC- has predicted O-linked glycans PLUS ENaC- has another proline, serine, threonine rich stretch - a likely mucin domain - OC43 and HKU1 Spike also have this.
Slack / Private Message Drop, p.57 · original PDF · in context
"RTT plot for Ebola is super interesting" Agree - how do the RBDs align on the different branches?
Slack / Private Message Drop, p.57 · original PDF · in context
She has won two PulitzerPrizes, for her series "The DNA Age", and as part of a team for the series "How Race Is Lived inAmerica." @amy_harmon • Facebook
Slack / Private Message Drop, p.62 · original PDF · in context
Laurie Garrett was just on the teevee and said that if social distancing etc had not been implemented a half a billion people would be dead now or dead shortly from now.
Slack / Private Message Drop, p.62 · original PDF · in context
"Disease ecologist Peter Daszak, president of the nonprofit EcoHealth Alliance in Manhattan, said the Harvard study"is absolutely fascinating."
Slack / Private Message Drop, p.64 · original PDF · in context
Yes, curefinder is especially lame when you haven't - you know - like actually found anycures.
Slack / Private Message Drop, p.65 · original PDF · in context
https://www.theguardian.com/commentisfree/2020/jun/09/conspiracies-covid-19-lab-false-pandemic?CMP=share_bt n_tw "Writing in the peer-reviewed journal Nature Medicine, researchers strongly refuted the idea that the code had been purposefully manipulated.
Slack / Private Message Drop, p.67 · original PDF · in context
Whereas the article in Nature Medicine_ _was written by senior virologists, one author, John Fredrik Moxnes, the chief scientific adviser to the Norwegian military, has already withdrawn his name from the paper cited by Dearlove - while scientists from the Francis Crick institute and Imperial College London also dismissed its conclusions." I think he's calling us old, but whatever....
Slack / Private Message Drop, p.67 · original PDF · in context
"exactly where they inserted it experimentally in SARS" Sure - but that site with the single R is a required cleavage site - if you're going to convert to a furin site then adding RRA at that exact position is the only thing that makes sense - or even RRAR to make it a super-optimal site like Nunberg did - what would not make sense is to stick aproline in and then to do the whole insertion out-of-frame.
Slack / Private Message Drop, p.69 · original PDF · in context
HKU1 actually does have an optimal furin site - some strains have a insert or deletion of SSS - yes some of these Shave predicted O-glycans [shared file(s): HKU-1 Spike.pdf]
Slack / Private Message Drop, p.69 · original PDF · in context
The CoVs from the frothy pangolins are pretty diverse - multiple introductions, long time evolving or both?
Slack / Private Message Drop, p.74 · original PDF · in context
IOWS what is the Proximal Origin of Pangolin-SARS?
Slack / Private Message Drop, p.74 · original PDF · in context
"We have two choices: just ignore it or make a group response...it's up to the WIV to deal with this, not us." I agreewe should ignore this BBC effort and whomever they've co-opted for their show.
Slack / Private Message Drop, p.77 · original PDF · in context
There is a third way - a commission - WHO or other - to look into the proximal origins - would give WIV a chance toclear themselves.
Slack / Private Message Drop, p.77 · original PDF · in context
To show our appreciation for your time and contribution, we would like to offer an honorarium of $150.
Slack / Private Message Drop, p.80 · original PDF · in context
Such experiments, if designed to define potential immune correlates or winnow out less effective vaccineapproaches, may have utility.
Slack / Private Message Drop, p.89 · original PDF · in context
Moreover, partial efficacy in young healthy adults does not predict similar effectiveness among older adults with major cofactorsassociated with COVID-19 disease, nor would it prove reduction of transmissibility to major susceptibility groups.
Slack / Private Message Drop, p.89 · original PDF · in context
Whether such experiments may be worthy of pursuit or would have a beneficial impact on timelines for vaccine development needs careful evaluation by an independent panel of ethicists, clinical trialists, and experts on vaccine development.
Slack / Private Message Drop, p.89 · original PDF · in context
Lots ofhydroxychloroquine was poured into COVID patients.
Slack / Private Message Drop, p.90 · original PDF · in context
Passing RaTG13 in human cells would not have generated the pangoCoV RBD.
Slack / Private Message Drop, p.95 · original PDF · in context
Furthermore, WIV hasn't exactly been hiding RaTG13, but they may be itching to get back there as well.
Slack / Private Message Drop, p.95 · original PDF · in context
Could be the straw that pushes us to Proximal Origin 2 perhaps...
Slack / Private Message Drop, p.95 · original PDF · in context
but unfortunately it's not what they doinghttps://www.forbes.com/sites/brucejapsen/2020/06/02/fauci-modernas-phase-3-covid-19-vaccine-trial-will-include-30000-young-and-old-individuals/#316e15174f75
Slack / Private Message Drop, p.104 · original PDF · in context
Basically for Moderna they are immunizing/placeboing 30,000 people then sending them out to see how many get infected.
Slack / Private Message Drop, p.104 · original PDF · in context
Probably not, but if they are giving them the proper advice - mask upsocial distance etc - you should have VERY FEW infections in the 30,000.
Slack / Private Message Drop, p.105 · original PDF · in context
Enough safety data should be there in the Phase I and II trials - you're right that the Moderna safety data is HIGHLY suspect.
Slack / Private Message Drop, p.105 · original PDF · in context
Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.
Slack / Private Message Drop, p.105 · original PDF · in context
Speaking of "nice" - Mikovitz is back https://www.vice.com/en_us/article/7kpe3b/the-star-of-plandemic-spent-years-flooding-the-vaccine-court-system-with-bad-science
Slack / Private Message Drop, p.107 · original PDF · in context
https://www.msn.com/en-us/health/medical/close-relatives-of-the-novel-coronavirus-may-have-circulated-in-bats-for-decades-before-jumping-to-humans/ar-BB17gNfN This piece is also likely to show up in _Scientific American_ according to the reporter, who works both for the paper and _SciAm_.
Slack / Private Message Drop, p.114 · original PDF · in context
BTW - Proximal Origins is at 4.87m accesses - seems destined to cross 5m in a few weeks, which is actually quite remarkable.
Slack / Private Message Drop, p.117 · original PDF · in context
Rather, our aim was to carefully examine in a balanced and unbiased manner the evidence for and against a number of possible probable scenarios for the proximal origins of SARS-CoV-2.* But more importantly this reviewer feels, and we agree, that the Perspective would quickly become outdated when more scientific data are published (for example on potential reservoir hosts).*Of course, it is likely that more scientific data will swing the balance in favor of one hypothesis over another.
Slack / Private Message Drop, p.121 · original PDF · in context
It's an OK response - she probably had to consult a lawyer to allow use of the term "disappointing, if." Consider thisa successful immunization if DT tries to push this further with Nature or if DT tries for some other journalist.
Slack / Private Message Drop, p.126 · original PDF · in context
https://www.snopes.com/fact-check/fauci-quote-hydroxychloroquine/ In-box is filling up with VJ "stuff."
Slack / Private Message Drop, p.131 · original PDF · in context
NBC News correspondent Janis MacKey Frayer was granted a tour of the WIV BSL 4 labs on Friday -- the first international correspondent to do so since the Covid outbreak.
Slack / Private Message Drop, p.132 · original PDF · in context
Because that was several months ago now (feels like a lifetime ago!),I wanted to get an update from you as to whether you still feel that it is impossible orimprobable that the outbreak started from the WIV labs in any form.
Slack / Private Message Drop, p.132 · original PDF · in context
What I can't really imagine is the conversations Lauer had - with say the CIA - to lead him to ask Daszak that series of questions.
Slack / Private Message Drop, p.140 · original PDF · in context
"Bob and I are now officially in the same 'Family' as the Grand Wizard of EgoHealth." This make me more than a "little bit nauseous," but so be it.
Slack / Private Message Drop, p.151 · original PDF · in context
Agree with all this - yeah fishy - but very troubling especially if the second round was worse than the first in some cases.
Slack / Private Message Drop, p.152 · original PDF · in context
A treasure-trove of data on transmission amongst young nearly all asymptomatic individuals and their aggressively sought out contacts who are placed in quarantine.
Slack / Private Message Drop, p.153 · original PDF · in context
However, the issue of insertions and particularly deletions (including deletions near the furin site) is a real thing - becoming a problem with the animal models according to a discussion I was having with respiratory pathogens branch at CDC on Friday - if the stocksare not properly grown [ie by passing a low MOI} the furin site gets screwed and the viruses are no longer pathogenic in animals.
Slack / Private Message Drop, p.154 · original PDF · in context
Related - worried about ongoing vaccine trials - rumbles are could all be major disasters inprogress under the hot spotlights [human and animal versions].
Slack / Private Message Drop, p.154 · original PDF · in context
Live challenges (yes - @Kristian Andersen I agree -no placebo) may be they only way out to find vaccines that actually work.
Slack / Private Message Drop, p.154 · original PDF · in context
I'm pretty sure he's going to try to do this - esp as the poll numbers either stay the same or more likely move a bit more to Biden/Harris - this is literally who he is and nothing else other than getting re-elected matters in the least -I'm also pretty sure this is going to be a line in the sand for not only the vaccine manufacturers but the FDA, NIH, even the Warp Speed commandos themselves - be ready to speak out.
Slack / Private Message Drop, p.154 · original PDF · in context
Attached please find a formal request for retraction of the Nature Medicine article, "The proximal origin of SARS-CoV-2." Representatives of Nature Medicine, the Springer Group, the authors and their associated institutions, and relevant medical journal affiliates have been copied in this request.
Slack / Private Message Drop, p.156 · original PDF · in context
Good thing "Xander" appears not to have a clue about FOIA, actually something that can't be round-filed.
Slack / Private Message Drop, p.157 · original PDF · in context
I'm a little more optimistic that immunity, natural or vaccine, will impact the spread of SARS-CoV-2.
Slack / Private Message Drop, p.161 · original PDF · in context
I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains.
Slack / Private Message Drop, p.162 · original PDF · in context
https://www.huffingtonpost.it/entry/e-possibile-creare-un-virus-in-laboratorio-senza-lasciare-traccia-la-risposta-dellesperto_it_5f5f3993c5b62874bc1f7339 "So you rule out that SARS-CoV-2 is a laboratory chimera? we ask him.
Slack / Private Message Drop, p.164 · original PDF · in context
https://www.thedailybeast.com/steve-bannon-linked-groups-push-study-claiming-china-manufactured-covid?ref=scr oll - it's a start, but a note to Angie that furin sites are not YET found in other bat-CoVs.
Slack / Private Message Drop, p.172 · original PDF · in context
The pangolin CoVs (that Alina seems focused on) and other BtCoVs were sufficient for the Proximal Origins analysis.
Slack / Private Message Drop, p.178 · original PDF · in context
What I think will happen is that in the pursuit of objectivity Lancet's team will fell obliged to swipe"mightily" at Proximal Origins (cause GVP is a scam, we know it and we're noncoronavirologists) and present asuper-lame counter to Yan/Chan.
Slack / Private Message Drop, p.180 · original PDF · in context
It's mind-blowing that Sachs/Horton appear to have no appreciation how terrible a choice this was.
Slack / Private Message Drop, p.182 · original PDF · in context
```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV.
Slack / Private Message Drop, p.185 · original PDF · in context
It's another data point that I believe shows that the furin site in SARS2 could evolve naturally.
Slack / Private Message Drop, p.185 · original PDF · in context
Maybe it's my mean streak, maybe it's just that I think that Daszak is going to screw it up or maybe I think the RBG September surprise has shook up the Presidential race, but the "*IT ESCAPED FROM WIV*" crowd is empowered not depowered at the moment - science literally bedamned.
Slack / Private Message Drop, p.185 · original PDF · in context
Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally.
Slack / Private Message Drop, p.186 · original PDF · in context
And the expertise of the Chinese government and their laboratories found that the virus was changed to specifically target humans in the laboratory.As for whether there is a vaccine for Wuhan pneumonia in China, Yan Limeng pointed out that China uses traditionalmethods to produce the virus, but vaccine development and antidote are another matter.
Slack / Private Message Drop, p.188 · original PDF · in context
"First of all, this (virus) isan enhanced version of SARS-1..., but until today We know that there is still no vaccine for SARS-1." Regarding the future global epidemic, she said: "(The virus) has caused a historical pandemic.
Slack / Private Message Drop, p.188 · original PDF · in context
https://pubmed.ncbi.nlm.nih.gov/32869021/ Furin site is important
Slack / Private Message Drop, p.189 · original PDF · in context
Mightbe coming - that BillyBostickson persona, who is documenting the ties of the Proximal Origins authors to the CCP, has ties to Alex Berenson.
Slack / Private Message Drop, p.192 · original PDF · in context
Then, you have the made in a lab crowd, the accidental release crowd [sorta like Hooper], the Plandemiccults and the deniers pouring out from the woodwork and from under their rocks.
Slack / Private Message Drop, p.195 · original PDF · in context
COVID-19 whips it all up [with the help of social media] into an extra toxic stew by adding in international politics [with more than a hint of racism although AIDS had/has that too] and of course the Fox/Bannon/Trumpists.
Slack / Private Message Drop, p.195 · original PDF · in context
Anther thing Wakefield taught Daszak was the power of science by press conference: "Although the paper said thatno causal connection had been proven, before it was published, Wakefield made statements at a press conference and in a video news release issued by the hospital, calling for suspension of the triple MMR vaccine until more research could be done.
Slack / Private Message Drop, p.196 · original PDF · in context
Trump begins quarantine as close aide Hope Hicks tests positive for coronavirus President Trump told Fox News's Sean Hannity during a live interview Thursday night that he and the first lady were tested after they learned about Hicks and were planning to quarantine.
Slack / Private Message Drop, p.201 · original PDF · in context
Trump in quarantine is a pretty big deal - this will be interesting...
Slack / Private Message Drop, p.201 · original PDF · in context
What are we supposed to do - spend a couple of billion and make vaccines to these viruses?
Slack / Private Message Drop, p.209 · original PDF · in context
Kayleigh McEnany and 2 others in the WH communications office are positive.
Slack / Private Message Drop, p.212 · original PDF · in context
"could any standard patient lead to these events, or does it take something special" It's probably both - put your standard patient in the right situation [like the WH gala or a bar]- they will SS.
Slack / Private Message Drop, p.212 · original PDF · in context
I also think there are likely special patients that exist that spread especially well and that very high virus load is a major discriminator btwn the standard and special patients.
Slack / Private Message Drop, p.212 · original PDF · in context
That being said we're about to put something up on virological - might run it by here first - showing serorxty to SARS-CoV-2, N, Sand RBD in samples from SL back to 2008.
Slack / Private Message Drop, p.214 · original PDF · in context
Still cleaning up the dataset.*Cross-reactive antibodies to SARS-CoV-2 nucleoprotein, spike and receptor binding domain in pre-COVID-19 plasma and serum samples from Sierra Leonians.* A mystery regarding the COVID-19 pandemic has been the relatively low case numbers and fatality rates in most countries in Sub-Saharan Africa compared to many other countries worldwide (Mbow et al., 2020).
Slack / Private Message Drop, p.214 · original PDF · in context
This important study raises the possibility that a novel betacoronavirus(es) related to SARS-CoV and SARS-CoV-2 is present in African bats.To investigate possible exposure to betacoronavirus proteins in Africans we tested plasma and serum samples collected before the reporting of the first Chinese COVID-19 cases in late 2019 for the presence of antibodies that bind to SARS-CoV-2 nucleoprotein, spike or receptor binding domain (RBD).
Slack / Private Message Drop, p.214 · original PDF · in context
RBD (residues 319-591) and "HexaPro" S (Hsieh et al., 2020)were transiently transfected into FreeStyle 293-F cells.
Slack / Private Message Drop, p.214 · original PDF · in context
The HexaPro Spike and RBD were further purified by size-exclusionchromatography.
Slack / Private Message Drop, p.214 · original PDF · in context
Significant numbers of positive ELISA reactivities to SARS-CoV-2 N, S and RBD were observed in serum and plasma samples from the Ebola survivor cohort.
Slack / Private Message Drop, p.214 · original PDF · in context
As expected there was a correlation between reactivities to trimericS and RBD (p < .0001).
Slack / Private Message Drop, p.214 · original PDF · in context
Significant correlations were also observed between the reactivities to N and S (P=.003)or N and RBD (p < .0001).
Slack / Private Message Drop, p.214 · original PDF · in context
Using conservative cutoffs, 43% of samples (83/192) were positive for reactivity toeither the SARS-CoV-2 N and/or the RBD. 33/192 were reactive to both N and RBD, 19/192 were reactive to N only and 31/192 were reactive to RBD only.
Slack / Private Message Drop, p.214 · original PDF · in context
Similar results were obtained in comparing the reactivities of N to S.Differences in reactivities to N and S or RBD are expected and similar to differential reactivities observed for LASVnucleoprotein versus glycoprotein (Heinrich et al., 2020).The distribution of the positive samples over the time of collection appears to be non-random.
Slack / Private Message Drop, p.214 · original PDF · in context
Scientists such as Lipkin and this Anderson, as well as such scientists as Malik, PanLiewen, Cao Wuchun, Chen Wei, Chen Fang, Shi Zhengli, etc., show the degeneration of human nature, the loss and sorrow of the scientific spirit.
Slack / Private Message Drop, p.219 · original PDF · in context
In order to be promoted from associate professor toprofessor, they can be more "developed" in the mainstream science world, and they can ignore the life and death ofthe world. dignity.
Slack / Private Message Drop, p.219 · original PDF · in context
It an old song, but true today "Clowns to the left of me, Jokers to the right, here I am,.." https://www.organicconsumers.org/blog/gain-function-ghouls-sars-cov-2-isnt-scariest-thing-could-leak-lab "It's been less than a year since SARS-2 somehow escaped from a lab in Wuhan, China, infecting millions, triggering serious illness and death among the elderly (especially those in nursing homes) and those with serious pre-existing chronic diseases (obesity, diabetes, hypertension, and heart, lung and liver disease), and melting down the global economy."
Slack / Private Message Drop, p.223 · original PDF · in context
If we can get Trump to tweet about how "Proximal Origins authors paid off with CCP honeys," we'll be back at #1 on Altmetric in no time.
Slack / Private Message Drop, p.227 · original PDF · in context
I'd add to Kristian's list TV science "experts" [especially those that fake the disease they are spreading disinformation about], outbreak culture in general and - related to the latter - "science" by Zenado/internet [Yan}/twitter {Chan}.
Slack / Private Message Drop, p.229 · original PDF · in context
Alina's new BFFs: https://threadreaderapp.com/thread/1320376404102377472.html "Unpublished passage experiment in either human cells or humanized mice, which resulted in the accidental "sampling" of internal GOF work that were then erroneously reported as a "coronavirus infection" in the pangolin samples, leading to the Viruses paper by Liu et al."
Slack / Private Message Drop, p.231 · original PDF · in context
Beyond the accusations that the bat and pangolin sequences are fraudulent is the whole FCS is a :unicorn_face: BSand that no one has ever seen a FCS generated that way before.
Slack / Private Message Drop, p.234 · original PDF · in context
Earlier cases in Wuhan would not be all that much of a surprise (of course that was predicted in Proximal Origins).
Slack / Private Message Drop, p.247 · original PDF · in context
Maybe just a coincidence but Alina is recommending this "Jess." I'm still waiting for my pity award, but a nice wad ofcash from CCP would do as well I suppose. [shared file(s): image.png]
Slack / Private Message Drop, p.247 · original PDF · in context
Probably the same WHO 'insiders' who insisted for months that SARS-CoV-2 was mostly spread by fomites [just wash your hands and use a pencil to touch elevator buttons], was NOT airborne, forgot to advise about social distancing/isolating cases and discouraged mask use.
Slack / Private Message Drop, p.255 · original PDF · in context
BTW - The other guest with the BL inspector was David Tully who VR has been supporting via TWiV in a long-standing but lesser known than the MMR war against Lancet over some chronic fatigue/ME papers.
Slack / Private Message Drop, p.257 · original PDF · in context
At least 45 and associatedclowns are on the way out....
Slack / Private Message Drop, p.258 · original PDF · in context
One example of many logical fallacies [https://thebestschools.org/magazine/15-logical-fallacies-know/] is the strawman: "Scientists who are convinced of the natural origin base their belief on *Occam's razor*: epidemics from the past have shown that these things do happen in nature, so the simplest explanation is that it happened this time too."
Slack / Private Message Drop, p.259 · original PDF · in context
What's not known [here's the speculation] is if the NTD of SARS-CoV2 (where the 69/70 deletion is actually part of a receptor binding domain forsialic acid or other molecule.
Slack / Private Message Drop, p.261 · original PDF · in context
Would be "ironic" if a poorlydone epi projection, an old HCQ paper from VJ and a not-so-well done mask study all beat out Proximal Origins onAltmetric....
Slack / Private Message Drop, p.263 · original PDF · in context
*I do agree that Proximal Origins 2 should happen sooner than later - just not certain of the best approach or approaches -we seem to have attracted some attention with PO1 so a sequel - given the persistence of the unnatural crowd would likely be noticed. @Andrew Rambaut has made a good start.
Slack / Private Message Drop, p.268 · original PDF · in context
*Naturally occurring indels in multiple coronavirus spikes* *Introduction* Proponents of theories for the unnatural origin of SARS-CoV-2 have asserted that the 12 nucleotide insert in the SARS-CoV-2 spike gene, which results in acquisition of a furin cleavage site, may have arisen by laboratory manipulation (Relman, 2020; Segreto and Deigin, 2020; Seyran et al., 2020; Sirotkin and Sirotkin, 2020).
Slack / Private Message Drop, p.268 · original PDF · in context
Here, wecompile evidence demonstrating that that insertion/deletion (indel) events at the S1/S2 and S2' protease cleavage sites of the spike precursor are commonly occurring natural features of coronavirus evolution.
Slack / Private Message Drop, p.268 · original PDF · in context
O-linked glycosylation sites were predicted by Net-O-Glyc v. 4.0 (Steentoft et al., 2013).*Results* While recent analyses suggest the existence of as yet unsampled sarbecovirus lineages, it is likely that SARS-CoV-2 and recently described coronaviruses isolated from pangolins share common ancestors with the bat sarbecovirus RaTG13 (Boni et al., 2020).
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HKU24, OC43 and Betacoronavirus 1spikes have optimal furin cleavage sites (Fig. 1A).
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Furin cleavage sites are present in spikes of other coronaviruses.
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Type I feline coronavirus spikes have an optimal furin cleavage site, whereas Type II feline coronavirus spikes lack either a monobasic or polybasic cleavage site at theS1/S2 junction (Fig. 1C).
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