Gain-of-function research

At the time there was the beginning of a moratorium by President Reagan and later Bush on the use of fetal tissue for transplantation into humans.

Diary Prequel Package, p.40 · original PDF · in context

I found out through painful probing that recommendations from NSABB  guidelines  USG policy should have been in place years ago to deal with the upstream (prior to the start of experiments) and downstream (progress reports and communication of results) issues of Dual Use Research of Concern (DURC).

Diary Prequel Package, p.263 · original PDF · in context

Let me be clear, I believe that we need to now once and for all get the process going of a SOP for evaluating dual use research of concern (DURC) before the experiments are performed to evaluate the risk/benefit of even doing the experiments and to periodically look at the data to determine whether the data should be shared (presented or published) before one presents it or submits it to a journal.

Diary Prequel Package, p.263 · original PDF · in context

Also, on the first day of the meeting (March 29), the USG (mainly NSS) came out with the official DURC Policy that guides how we should approach DURC.

Diary Prequel Package, p.281 · original PDF · in context

At the meeting, Richard Roberts (1993 Nobel Laureate and known Gadfly) came to the microphone and said that many virologists who disagree with Francis Collins and me about doing DURC are afraid to speak up because they fear retribution and will not get their grants funded - Holy Shit!!

Diary Prequel Package, p.285 · original PDF · in context

They are proposing that the USG create an Interagency Committee with final authoritative power to decide what DURC experiments can and cannot be done.

Diary Prequel Package, p.287 · original PDF · in context

They still do not "get it' and think with all the public furor that they can just go on and do these DURC experiment without full public by-in and comment.

Diary Prequel Package, p.292 · original PDF · in context

Over the past few days that has been continued activity concerning the dual use research of concern issue particularly regarding highly pathogenic H5N1 influenza virus.

Diary Prequel Package, p.294 · original PDF · in context

Discussed the issues around DURC and how we are going to address the voluntary (on the part of the scientists) moratorium on gain-of-function for transmissibility in mammals research on highly pathogenic avian H5N1 influenza.

Diary Prequel Package, p.295 · original PDF · in context

These principles could then serve as the basis for guidelines for DURC that go well beyond H5N1.

Diary Prequel Package, p.295 · original PDF · in context

I have written a commentary to appear soon in mBio (online Journal of the ASM) that asks for keeping the moratorium on H5N1 gain-of-function until the abovementioned December meeting.

Diary Prequel Package, p.295 · original PDF · in context

The nay-sayers who feel this research should not be done at all (David Relman, John Roberts (Nobel Prize winning ass-hole) or should not be published (Mike Osterholm) are still out there bad-mouthing the decision to lift the moratorium.

Diary Prequel Package, p.304 · original PDF · in context

They have been consistently against gain-of-function research, especially on influenza.

Diary Prequel Package, p.348 · original PDF · in context

I have suggested to Francis and he agrees that we call a temporary moratorium on all gain of function research on influenza and the MERS virus involving increasing pathogenesis and increasing transmissibility by the respiratory route.

Diary Prequel Package, p.348 · original PDF · in context

On the debit side I was just sent another (long) piece of conspiracy theory BS: https://medium.com/@yurideigin/labmade-cov2-genealogy-through-the-lens-of-gain-of-function-research-f96dd7413748

Slack / Private Message Drop, p.19 · original PDF · in context

On page 192 of SF 424 AI110964-06 (received date 11/05/2018) under P3CO Research, it indicates they are conducting gain of function of SARSr-CoV.

Reading Room Production, p.5 · original PDF · in context

The replacement policy, Potential Pandemic Pathogen Care and Oversight (P3CO), requires additional review and oversight of experiments that are anticipated to increase a potential pandemic pathogen's transmissibility or pathogenicity in humans.

Reading Room Production, p.5 · original PDF · in context

There may be some misunderstanding of gain-of-function experiments, so hopefully this will clarify some things or at least provide a framework for our discussion next week.

Reading Room Production, p.5 · original PDF · in context

On page 192 of SF 424 AI110964-06 (received date 11/05/2018) under P3CO Research, it indicates they are conducting gain of function of SARSr-CoV.

Reading Room Production, p.5 · original PDF · in context

The replacement policy, Potential Pandemic Pathogen Care and Oversight (P3CO), requires additional review and oversight of experiments that are anticipated to increase a potential pandemic pathogen's transmissibility or pathogenicity in humans.

Reading Room Production, p.5 · original PDF · in context

Most important is that you need a very close relative (99% or better) to get to SARS-CoV-2 by any sort ofGOF research.

Slack / Private Message Drop, p.499 · original PDF · in context

People like Matt Ridley, Ebright, Filipa (alina's buddy), Lipstich etc have a long history of railing against human caused outbreaks or antiGOF research.

Slack / Private Message Drop, p.516 · original PDF · in context

Ridley hopes to make bank on the CIVID book he's writing - Metzl, that idiot Rogan and several others as well - the more notorious they are the more books they hope to sell. eDIm, Fillipa and Lipstich has a lot of their professionalcapital invested in finding that BSL-4 labs and GoF research are deadly.

Slack / Private Message Drop, p.647 · original PDF · in context

The eDims and Filippas of the world are going to use this to achieve their goal of shutting down GoF research which they will define as any genetic manipulation of a virus.

Slack / Private Message Drop, p.693 · original PDF · in context

@Eddie Holmes The timing of all of the sequence information on sarbecoviruses is really the most definitive proof that SC2 is not a product of engineering, cell culture passage or GoF research.

Slack / Private Message Drop, p.711 · original PDF · in context

The usual cast of characters that had been bugging us about gain of function research or add it again claiming incorrectly that we have funded gain of function research for the Wuhan lab.

Tony's Diary Package, p.728 · original PDF · in context

They seem to be hung up on the fact that they believe that we have funded gain of function research for the lab when in fact we have not.

Tony's Diary Package, p.728 · original PDF · in context

In the meantime, senator Rand Paul has introduced an amendment to ban gain of function research in China.

Tony's Diary Package, p.751 · original PDF · in context

Politifact is fact-checking whether Tony Fauci is lying about funding GoF research at WIV - Tony is smart - I'm sure he's not lying. @Kristian Andersen you're right they are pointing at the PLOS Pathogens paper.

Slack / Private Message Drop, p.812 · original PDF · in context

The HHS people are misguided thinking that by explaining the grant as well as what gain of function really means we will be calling attention to 'public 800,000/584,300 the issue.

Tony's Diary Package, p.740 · original PDF · in context

They were very reluctant to have us put a statement on the NIH director's website concerning the gain of function issue.

Tony's Diary Package, p.740 · original PDF · in context

One of the real problems is that people are conflating whether or not we approved gain of function research for Wuhan and the possibility that the Chinese created SARS-C0V-2 in the laboratory.

Tony's Diary Package, p.741 · original PDF · in context

He was very emphatic that the work that was done at the Wu Han Institute in Association with our grant was not gain of function .

Tony's Diary Package, p.746 · original PDF · in context

To DD points which is a good one, 6 of the 18 Bloomshitters (BS) were also members of the Cambridge Working Group (CWG)opposing GoF research.

Slack / Private Message Drop, p.856 · original PDF · in context

They completely misconstrued it to say that I was in favor of gain of function research even if it meant the risk of a pandemic.

Tony's Diary Package, p.753 · original PDF · in context

In one sequence of emails Inoticed you were part of an early February 2020 conference call involving several experts discussing what appearsto be, at least in part, gain-of-function research.

Slack / Private Message Drop, p.908 · original PDF · in context

He referred to the Plos Pathogens paper of 2017 and insisted that there was gain of function in those experiments and said I therefore lied.

Tony's Diary Package, p.813 · original PDF · in context

The moratorium expired and the Supreme Court ruled that they could not reinstitute it.

Tony's Diary Package, p.831 · original PDF · in context

Larry Horowitz who works with Pelosi called me to ask me to try and convince Rochelle to reinstitute the moratorium, get sued (which she will lose ), and thus give enough time to get money to the people who are being evicted to prevent their eviction.

Tony's Diary Package, p.831 · original PDF · in context

Second, he is concerned about the fact that the moratorium on evictions of people from their homes has expired and the Supreme Court has voted five to four that the moratorium cannot be extended.

Tony's Diary Package, p.832 · original PDF · in context

He has the power to call together constitutional scholars and claim that they have given him enough reason to overrule the opinion of the Supreme Court and order the CDC to continue with the moratorium on evictions.

Tony's Diary Package, p.832 · original PDF · in context

In addition, I am concerned that even good scientists playing a game of using their longstanding concern with gain of function to call attention to this by what is going on regarding the argument about the origin of the virus.

Tony's Diary Package, p.847 · original PDF · in context

Confirmed Cases (Thousands) = b bh Mm wu ab a Lh a2 Li a Lh oa S oa S oa S Ln a the shadows 38,500,000/632,800 New Daily Confirmed COVID-19 Cases in the U.S. 2020/2021 165.9 PRESS: Washington Post: A science in the shadows Controls on 'gain of function' experiments with supercharged pathogens have been undercut despite concerns about lab leaks By David Willman and Madison Muller

Tony's Diary Package, p.860 · original PDF · in context

This created and expected firestorm of tweets that I had lied to the Congress and that gain of function actually took place and I covered it up.

Tony's Diary Package, p.872 · original PDF · in context

I must make a point that over the last few weeks more intensively over the last few days I have been stressed beyond the limit particularly compounded by the dark web far right maniacs continuing to attack me in the area of gain of function research, accusations of lying to the Congress under oath, and a variety of other conspiratorial accusations.

Tony's Diary Package, p.879 · original PDF · in context

I am terribly disappointed with Jesse Bloom and David Relman for doing somewhat of the same thing. they have been pushing to stop any gain of function research for a long time and I believe that in some respects they are pushing for an even hoping that this was a lab leak , which the molecular analysis of the viruses that we used in the lab compared to the virus SARS-CoV-2 clearly indicate that it is molecularly impossible for the viruses under the auspices of the NIH grant to have been manipulated into or evolved into SARS-Cov-2.

Tony's Diary Package, p.888 · original PDF · in context

However what people will not appreciate is that even with that increase in pathogenicity, the experiment and the result still does not fall under the category that would trigger P3CO.

Tony's Diary Package, p.896 · original PDF · in context

In other words, According to the operable definition of gain of function of concern at the time, this was not gained a function of concern.

Tony's Diary Package, p.896 · original PDF · in context

They do not understand nor do they seem to want to understand that we were operating under the framework of P3CO which clearly indicates that the experiments that were funded by the NIH in Wuhan fell under that auspices and were properly conducted according to the existing guidelines at the time.

Tony's Diary Package, p.906 · original PDF · in context

In other words by our definition, it was not gain of function.

Tony's Diary Package, p.907 · original PDF · in context

We are putting out a statement indicating that we knew nothing of these experiments and they should have told us about them and put it through the P3CO process.

Tony's Diary Package, p.1085 · original PDF · in context

ORS Concern over the confusion and differences between agent listing, some definition and intent of this as compared to the new DURC PEPP policy and also the current/ transparent process by which select agents are added or removed.

Reading Room Production, p.137 · original PDF · in context

ORS Concern over the confusion and differences between agent listing, some definition and intent of this as compared to the new DURC PEPP policy and also the current/ transparent process by which select agents are added or removed.

Reading Room Production, p.164 · original PDF · in context

One of the calendar invites that we have says that the purpose of the discussion, for you coming in, was to discuss basic research that is gain-of-function, that will further understanding of coronaviruses and corona vaccine development, and two, to address the slowness of the U.S. government P3CO process.

Baric Transcribed Interview (Redacted), p.27 · original PDF · in context

I sort of told them why we felt that the data didn't demonstrate a gain-of-function phenotype, and that was because there was no change or increased replication of the virus in human DC.Scheduling@LexitasLegal.com cells.

Baric Transcribed Interview (Redacted), p.33 · original PDF · in context

We have no evidence that USAID has funded gain-of-function research, and we certainly have not authorized gain-of-function research." Then Senator Paul talked about the paper, and her response was that she just said, unequivocally, that USAID has not authorized gain-of-function research.

Baric Transcribed Interview (Redacted), p.49 · original PDF · in context

So the details of the discussion about what's gain-of-function or what's not is dependent on NIH.

Baric Transcribed Interview (Redacted), p.51 · original PDF · in context

All I know is that the Trump administration has formed a committee to come up with final policy recommendations for what is gain-of-function and what's not.

Baric Transcribed Interview (Redacted), p.53 · original PDF · in context

Now, if you want to know, down to the nucleotide level, what drives a cross-species jumping event, you are talking gain-of-function experiments.

Baric Transcribed Interview (Redacted), p.91 · original PDF · in context

They mention in there that this could involve gain-of-function research in their announcement.

Baric Transcribed Interview (Redacted), p.92 · original PDF · in context

And my interpretation of that was gain-of-function, and they discuss gain-of-function.

Baric Transcribed Interview (Redacted), p.95 · original PDF · in context

Now, I found it very interesting that the letter that they provided shortly thereafter said that the experiments were DURC.

Baric Transcribed Interview (Redacted), p.95 · original PDF · in context

DURC is Dual-Use Research of Concern. involving 15 pathogens, none of which is a coronavirus.

Baric Transcribed Interview (Redacted), p.95 · original PDF · in context

So if you go back to the NSABB P3CO regulations, the regulations state that viruses, like flu, SARS, and MERS coronavirus, are highly pathogenic viruses, and highly transmissible viruses are covered by this program.

Baric Transcribed Interview (Redacted), p.100 · original PDF · in context

And if you do anything on these particular viruses that are highly pathogenic or highly transmissible, and you do any manipulation to increase that, then that's considered gain-of-function and regulated by those documents, based on my read of them.

Baric Transcribed Interview (Redacted), p.100 · original PDF · in context

So is it only gain-of-function in that scenario if you know it's --

Baric Transcribed Interview (Redacted), p.102 · original PDF · in context

The only gain-of-function that you have ever done or been involved in is the one that you received an exemption for.

Baric Transcribed Interview (Redacted), p.112 · original PDF · in context