Chat message

Slack / Private Message Drop, p.985 [SLACK_001199] · slack_pm:msg:10269

Date: 2021-07-29 09:23
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Andrew Rambaut Actually "fun" to read those early posts and this document - the first version of this which appears to have been Feb 1, but maybe a version history wouls be interesting to look at. Pretty intense actually ----but I believe that the two factors that flipped the thinking were the mutational pattern in the RBD showing a likely natural pathway and the plethora of natural FCS and high variability at the S1/S2 junction. [shared file(s): image.png]

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Pretty intense actually ----but I believe that the two factors that flipped the thinking were the mutational pattern in the RBD showing a likely natural pathway and the plethora of natural FCS and high variability at the S1/S2 junction. [shared file(s): image.png]	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Pretty intense actually ----but I believe that the two factors that flipped the thinking were the mutational pattern in the RBD showing a likely natural pathway and the plethora of natural FCS and high variability at the S1/S2 junction. [shared file(s): image.png]

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-07-29 07:30 Andrew Rambaut open

Those three days are at the top of this slack channel!
2021-07-29 08:28 Kristian G. Andersen open

Correct - it's all really simple. I do appreciate they addressed the letter using my formal academic title, "Boss Man". Just so it's clear who's the boss here.
2021-07-29 08:30 Andrew Rambaut open

That is so cool. A keeper
2021-07-29 08:36 Kristian G. Andersen open

I'll frame it. Next to the frame with eDim insults.
2021-07-29 09:23 Robert F. Garry

@Andrew Rambaut Actually "fun" to read those early posts and this document - the first version of this which appears to have been Feb 1, but maybe a version history wouls be interesting to look at. Pretty intense actually ----but I believe that the two factors that flipped the thinking were the mutational pattern in the RBD showing a likely natural pathway and the plethora of natural FCS and high variability at the S1/S2 junction. [shared file(s): image.png]
2021-07-29 09:40 Kristian G. Andersen open

@Andrew Rambaut Yeah, I was looking through the version history recently - it's pretty interesting. We switched away from "engineering" quite a bit faster than I remembered - I think one of the main reasons being the comments from Ron, Marion, and Christian. And yes, a much closer look at all the available data.
2021-07-29 10:19 Robert F. Garry open

@Andrew Rambaut IOWS - science. Also good to remember that we were all literally scrutinizing the sequence since @Eddie Holmes posted it. So not an over-nite conversion.
2021-07-29 10:58 Andrew Rambaut open

@Andrew Rambaut When did RaTG13 and pango appear?

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