Chat message

Slack / Private Message Drop, p.186 [SLACK_000400] · slack_pm:msg:01919

Date: 2020-09-20 06:52
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

```ppttssrlrraTsg``` spike glycoprotein [BtPa-BetaCoV/GD2013] GenBank: AIA62343.1 This one is from another Merbecovirus a little closer to where it might have mattered in China. Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally. This one also has a predicted O-glycan, which may ormay not be used.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-20 06:52 Robert F. Garry

```ppttssrlrraTsg``` spike glycoprotein [BtPa-BetaCoV/GD2013] GenBank: AIA62343.1 This one is from another Merbecovirus a little closer to where it might have mattered in China. Bottom line, and maybe it's my myopia for not realizing this before, but there are bat betacoronaviruses inChina that have furin cleavage sites that evolved naturally. This one also has a predicted O-glycan, which may ormay not be used.
2020-09-20 06:54 Robert F. Garry open

pptistrlrratSgvS spike [Bat coronavirus (BtCoV/A434/2005)] GenBank: ABG11962.1 Here's the other onefrom china - two predicted O-glycans
2020-09-20 06:57 Robert F. Garry open

https://virological.org/t/the-sarbecovirus-origin-of-sars-cov-2-s-furin-cleavage-site/536 makes this conversation a bit more relevant - although that virological post seems to have been one of the factors that sent Alina down the rabbit hole.
2020-09-20 07:45 Robert F. Garry open

ppttsTrvrraTSgvsS spike glycoprotein [Pipistrellus abramus bat coronavirus HKU5-related] GenBank: QHA24687.1 best for last FOUR predicted O-glycans.

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