Chat message

Slack / Private Message Drop, p.380 [SLACK_000594] · slack_pm:msg:03952

Date: 2021-01-11 13:59
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Vaccines Intelligence community assessments Therapeutics and treatments

Recipients on this medium are inferred from channel membership, not per-message addressing.

https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.

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other https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast.	quoted / not their view	quoted_external sentence carries quotation marks	acknowledges
The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial.	quoted / not their view	quoted_external attribution frame: 'FDA said'	asserts
Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

quoted / not their view

quoted_external sentence carries quotation marks

acknowledges

The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial.

quoted / not their view

quoted_external attribution frame: 'FDA said'

asserts

Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-11 13:58 Andrew Rambaut open

Really struggling to work out what is going on.
2021-01-11 13:59 Andrew Rambaut open

It seems like all of these lineages are converging to the same set of mutations
2021-01-11 13:59 Edward C. Holmes open

I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours.
2021-01-11 13:59 Andrew Rambaut open

Oli will keep him right
2021-01-11 13:59 Robert F. Garry

https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.
2021-01-11 13:59 Edward C. Holmes open

:bomb:
2021-01-11 14:07 Robert F. Garry open

"It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.
2021-01-11 14:41 Andrew Rambaut open

The Japanese/Manaus cluster has the same nsp6 deletion that the UK and South African lineages have
2021-01-11 14:43 Edward C. Holmes open

Wowser. That's not chance.

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