Chat message

Slack / Private Message Drop, p.105 [SLACK_000319] · slack_pm:msg:01071

Date: 2020-07-23 09:08
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Therapeutics and treatments

Recipients on this medium are inferred from channel membership, not per-message addressing.

"fully understand what they're signing up for" - lay it out for them - they might die. We've got a 1000 dying each day just in the US. Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-07-23 09:01 Robert F. Garry open

Yes - it's definitely Trumps next trick for sure....
2020-07-23 09:02 Kristian G. Andersen open

He'd push it through - _even_ if we knew it was unsafe or even dangerous. No doubt. And that's bloody terrifying.
2020-07-23 09:02 Robert F. Garry open

Enough safety data should be there in the Phase I and II trials - you're right that the Moderna safety data is HIGHLY suspect.
2020-07-23 09:06 Kristian G. Andersen open

If I were a betting man, I'd put my money on ChAdOx1 and Sinovac - I'd forget anything RNA- or DNA-based for now- it's just too early for those platforms.
2020-07-23 09:08 Robert F. Garry

"fully understand what they're signing up for" - lay it out for them - they might die. We've got a 1000 dying each day just in the US. Yes - some trial participants could die - I think it's less likely with the better treatment regiments -dexy, remdesivir if they get in trouble - give them Ho or Crowe's MAbs.
2020-07-23 09:10 Robert F. Garry open

AGree about the RNA/DNA - There are other vectors that could work too - even VSV- the devil we know....
2020-07-23 09:11 Kristian G. Andersen open

True - maybe Ad26 too (I don't know enough about that one). Ad5 does not seem appealing, although I'm pretty sure China will approve it (CanSino).
2020-07-23 09:12 Robert F. Garry open

In my mind you definitely want the efficacy data first. If it doesn't work in young and health it won't work in the old and compromised.

Full conversation →