Chat message

Slack / Private Message Drop, p.380 [SLACK_000594] · slack_pm:msg:03954

Date: 2021-01-11 14:07
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

"It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry.	own voice, substantive	speaker_own	asserts
The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry.

own voice, substantive

speaker_own

asserts

The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-11 13:59 Edward C. Holmes open

I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours.
2021-01-11 13:59 Andrew Rambaut open

Oli will keep him right
2021-01-11 13:59 Robert F. Garry open

https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.
2021-01-11 13:59 Edward C. Holmes open

:bomb:
2021-01-11 14:07 Robert F. Garry

"It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.
2021-01-11 14:41 Andrew Rambaut open

The Japanese/Manaus cluster has the same nsp6 deletion that the UK and South African lineages have
2021-01-11 14:43 Edward C. Holmes open

Wowser. That's not chance.
2021-01-11 14:51 Robert F. Garry open

Places where the polymerase has tendency to slip and skip?
2021-01-11 15:05 Andrew Rambaut open

The Manaus/Japanese cluster has a very long branch (too long) - possibly another 'chronic infection' event?

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