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Slack / Private Message Drop, p.338 [SLACK_000552] · slack_pm:msg:03556

Page text: p.338 · original PDF

Date
2020-12-22 05:54
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Therapeutics and treatments

Recipients on this medium are inferred from channel membership, not per-message addressing.

The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant. K417, E484 and Q493 make the list of MARMs to various Regeneron MAbs (see Table 2). The presence of Q493K on the list of MARMs suggests that in the Baric and Sun mouse passage experiments immune section could have played a role in the emergence of the mouse pathogenic variant. https://science.sciencemag.org/content/369/6506/1014

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The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant. needs context uncertain explicit hedge asserts

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  1. 2020-12-22 05:54 Robert F. Garry
    The development of monoclonal antibody resistant mutants (MARMs) is an important clue that immune escape might be driving the emergence of the various Nellys and the elephant. K417, E484 and Q493 make the list of MARMs to various Regeneron MAbs (see Table 2). The presence of Q493K on the list of MARMs suggests that in the Baric and Sun mouse passage experiments immune section could have played a role in the emergence of the mouse pathogenic variant. https://science.sciencemag.org/content/369/6506/1014
  2. 2020-12-22 06:10 Robert F. Garry open
    Just noting that Q493K made the list of mutations discussed in channel above in the NEJM immunosuppressed patient who got the Regeneron MAbs.

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