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Slack / Private Message Drop, p.185 [SLACK_000399] · slack_pm:msg:01910

Date: 2020-09-19 08:59
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV. This sequence is from HKU5, which has a very MERS-like spike [ https://pubmed.ncbi.nlm.nih.gov/23720729/ ] and a somewhat better FCS than the minimal one inMERS-CoV. The capitalized STS are predicted O-glycans. Maybe these are used maybe not, but coincidences keep popping up {HKU1, OC43, MHC etc]. It's another data point that I believe shows that the furin site in SARS2 could evolve naturally. At the end of the day [thanks to this good work K and E] besides the wild thrashing around the "unusual" FCS is about all the Yans and Chans of the world are going to have left.

Links shared

gov https://pubmed.ncbi.nlm.nih.gov/23720729/

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV.	needs context	uncertain explicit hedge	asserts
It's another data point that I believe shows that the furin site in SARS2 could evolve naturally.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

needs context

uncertain explicit hedge

asserts

It's another data point that I believe shows that the furin site in SARS2 could evolve naturally.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-19 08:59 Robert F. Garry

```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV. This sequence is from HKU5, which has a very MERS-like spike [ https://pubmed.ncbi.nlm.nih.gov/23720729/ ] and a somewhat better FCS than the minimal one inMERS-CoV. The capitalized STS are predicted O-glycans. Maybe these are used maybe not, but coincidences keep popping up {HKU1, OC43, MHC etc]. It's another data point that I believe shows that the furin site in SARS2 could evolve naturally. At the end of the day [thanks to this good work K and E] besides the wild thrashing around the "unusual" FCS is about all the Yans and Chans of the world are going to have left.
2020-09-19 09:11 Robert F. Garry open

I think you should put this up in a peer-reviewed journal ASAP. Maybe it's my mean streak, maybe it's just that I think that Daszak is going to screw it up or maybe I think the RBG September surprise has shook up the Presidential race, but the "*IT ESCAPED FROM WIV*" crowd is empowered not depowered at the moment - science literally bedamned.
2020-09-19 09:17 Kristian G. Andersen open

Nah, I got more important papers to attend to - most importantly, one from NOLA :wink:. I'll put a summary up onVirological later today though - just so one can point to it.
2020-09-19 09:28 Robert F. Garry open

OK that should do it - next best thing. It will probably elicit more "Running Dog" commentary on the twitter. Maybe agood thing - you can add to your montage. Nature should give Batwoman a chance to respond to her accusers https://www.minervanett.no/alina-chan-coronavirus-covid19/contradicting-statements-cast-doubts-on-chinese-raw-data/364540 Nothing nefarious there. And yeah - Mardi Gras manuscript!

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