Chat message

Slack / Private Message Drop, p.162 [SLACK_000376] · slack_pm:msg:01652

Date: 2020-09-12 07:27
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

Unrelated - I'm looking for a good current Nidovirus tree. Fig 7 here seems good but I'm the *last* to judge a tree:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211748/ Other trees I've seen have artiviruses closer to toroviruses,but I think that's not correct. I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains. S2s are more flu-like (one long helix/leash) than the CoV S2s.

Links shared

gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211748/

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-12 06:58 Robert F. Garry open

Great job on the OpEd Eddie - the brilliance shines thru even with a heavy-handed editor.
2020-09-12 07:15 Robert F. Garry open

I'm a little more optimistic that immunity, natural or vaccine, will impact the spread of SARS-CoV-2. As Kristian knows [please keep this to the channel] we've found a fairly high level of serorxty to several SARS-CoV-2 proteins,N, S, RDB in Sierra Leonean samples going back several years. Some of the samples neutralize SARS-CoV-2pseudovirus. Probably a related betacoronavirus, but not a known seasonal CoV [HKU-1 or OC43]. May help explain (and I can't really fathom a lot of other explanations) why SARS-CoV-2 has not exploded in most of Africa. We're trying to get a dataset to post ASAP on Virological.
2020-09-12 07:27 Robert F. Garry

Unrelated - I'm looking for a good current Nidovirus tree. Fig 7 here seems good but I'm the *last* to judge a tree:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211748/ Other trees I've seen have artiviruses closer to toroviruses,but I think that's not correct. I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains. S2s are more flu-like (one long helix/leash) than the CoV S2s.
2020-09-12 07:38 Kristian G. Andersen open

I'm hopeful vaccines will be able to get us to where we need to be immunity wise, just not so sure about natural immunity and how long-lasting it is - but even if it isn't, there's still no doubt that it's already helping to drive down cases in at-risk areas. Let's see what happens in NYC this late fall / winter... Looking forward to seeing those cross-reaction results - very interesting!

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