Robert F. Garry

oppps...."One *Nature Medicine paper* further indicated that the pandemic virus shows no signs of having been engineered by scientists, another contention of conspiracy theorists.

Slack / Private Message Drop, p.6 · original PDF · in context

You are a scientist and not a politician but you looked like a very dull politician who has no idea what he was talking about.

Slack / Private Message Drop, p.20 · original PDF · in context

You have failed as a politician and you have tried to politicize this important and vital issue but you have failed successfully as a scientist as well. *Blame China for not telling the world everything, ganging with the WHO, and hoarding PPEs instead of blaming the President.*If bat corona research is so important, which I totally disagree with you, why then at least say that it is important but China should NOT be the one to conduct such a dangerous research because obviously they have no idea about what they are doing and the results are so obvious.

Slack / Private Message Drop, p.20 · original PDF · in context

And with that - Kristian will very much appreciate the fact for my own mental health - I'm getting back to work onother things.

Slack / Private Message Drop, p.28 · original PDF · in context

I'm the BBC Correspondent based in Beijing... and have, of course, been covering the outbreakof sars-covid-2 here in China since early this year.

Slack / Private Message Drop, p.33 · original PDF · in context

Ihave a few questions on which I would value your input related to the recent paper that you co-authored in Nature Medicine.In the first instance I was hoping for a brief background chat over the phone, but alternatively, if easier we couldconverse over email.

Slack / Private Message Drop, p.33 · original PDF · in context

It's obvious, but the only bits I'm really interested in are the RBD and the cleavage site of the progenitor of SARS-CoV-2.

Slack / Private Message Drop, p.34 · original PDF · in context

The 12base pair insertion is - as ProfBill pointed out - out of frame.

Slack / Private Message Drop, p.38 · original PDF · in context

Then there are the Mikovitses of the world who occupy their own special place.

Slack / Private Message Drop, p.43 · original PDF · in context

Yes, curefinder is especially lame when you haven't - you know - like actually found anycures.

Slack / Private Message Drop, p.65 · original PDF · in context

HKU1 actually does have an optimal furin site - some strains have a insert or deletion of SSS - yes some of these Shave predicted O-glycans [shared file(s): HKU-1 Spike.pdf]

Slack / Private Message Drop, p.69 · original PDF · in context

There is a third way - a commission - WHO or other - to look into the proximal origins - would give WIV a chance toclear themselves.

Slack / Private Message Drop, p.77 · original PDF · in context

To show our appreciation for your time and contribution, we would like to offer an honorarium of $150.

Slack / Private Message Drop, p.80 · original PDF · in context

Such experiments, if designed to define potential immune correlates or winnow out less effective vaccineapproaches, may have utility.

Slack / Private Message Drop, p.89 · original PDF · in context

Moreover, partial efficacy in young healthy adults does not predict similar effectiveness among older adults with major cofactorsassociated with COVID-19 disease, nor would it prove reduction of transmissibility to major susceptibility groups.

Slack / Private Message Drop, p.89 · original PDF · in context

Furthermore, WIV hasn't exactly been hiding RaTG13, but they may be itching to get back there as well.

Slack / Private Message Drop, p.95 · original PDF · in context

Basically for Moderna they are immunizing/placeboing 30,000 people then sending them out to see how many get infected.

Slack / Private Message Drop, p.104 · original PDF · in context

Enough safety data should be there in the Phase I and II trials - you're right that the Moderna safety data is HIGHLY suspect.

Slack / Private Message Drop, p.105 · original PDF · in context

NBC News correspondent Janis MacKey Frayer was granted a tour of the WIV BSL 4 labs on Friday -- the first international correspondent to do so since the Covid outbreak.

Slack / Private Message Drop, p.132 · original PDF · in context

Because that was several months ago now (feels like a lifetime ago!),I wanted to get an update from you as to whether you still feel that it is impossible orimprobable that the outbreak started from the WIV labs in any form.

Slack / Private Message Drop, p.132 · original PDF · in context

Agree with all this - yeah fishy - but very troubling especially if the second round was worse than the first in some cases.

Slack / Private Message Drop, p.152 · original PDF · in context

A treasure-trove of data on transmission amongst young nearly all asymptomatic individuals and their aggressively sought out contacts who are placed in quarantine.

Slack / Private Message Drop, p.153 · original PDF · in context

However, the issue of insertions and particularly deletions (including deletions near the furin site) is a real thing - becoming a problem with the animal models according to a discussion I was having with respiratory pathogens branch at CDC on Friday - if the stocksare not properly grown [ie by passing a low MOI} the furin site gets screwed and the viruses are no longer pathogenic in animals.

Slack / Private Message Drop, p.154 · original PDF · in context

Live challenges (yes - @Kristian Andersen I agree -no placebo) may be they only way out to find vaccines that actually work.

Slack / Private Message Drop, p.154 · original PDF · in context

I'm a little more optimistic that immunity, natural or vaccine, will impact the spread of SARS-CoV-2.

Slack / Private Message Drop, p.161 · original PDF · in context

I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains.

Slack / Private Message Drop, p.162 · original PDF · in context

https://www.huffingtonpost.it/entry/e-possibile-creare-un-virus-in-laboratorio-senza-lasciare-traccia-la-risposta-dellesperto_it_5f5f3993c5b62874bc1f7339 "So you rule out that SARS-CoV-2 is a laboratory chimera? we ask him.

Slack / Private Message Drop, p.164 · original PDF · in context

It's mind-blowing that Sachs/Horton appear to have no appreciation how terrible a choice this was.

Slack / Private Message Drop, p.182 · original PDF · in context

It's another data point that I believe shows that the furin site in SARS2 could evolve naturally.

Slack / Private Message Drop, p.185 · original PDF · in context

Mightbe coming - that BillyBostickson persona, who is documenting the ties of the Proximal Origins authors to the CCP, has ties to Alex Berenson.

Slack / Private Message Drop, p.192 · original PDF · in context

Then, you have the made in a lab crowd, the accidental release crowd [sorta like Hooper], the Plandemiccults and the deniers pouring out from the woodwork and from under their rocks.

Slack / Private Message Drop, p.195 · original PDF · in context

COVID-19 whips it all up [with the help of social media] into an extra toxic stew by adding in international politics [with more than a hint of racism although AIDS had/has that too] and of course the Fox/Bannon/Trumpists.

Slack / Private Message Drop, p.195 · original PDF · in context

Trump in quarantine is a pretty big deal - this will be interesting...

Slack / Private Message Drop, p.201 · original PDF · in context

Kayleigh McEnany and 2 others in the WH communications office are positive.

Slack / Private Message Drop, p.212 · original PDF · in context

Still cleaning up the dataset.*Cross-reactive antibodies to SARS-CoV-2 nucleoprotein, spike and receptor binding domain in pre-COVID-19 plasma and serum samples from Sierra Leonians.* A mystery regarding the COVID-19 pandemic has been the relatively low case numbers and fatality rates in most countries in Sub-Saharan Africa compared to many other countries worldwide (Mbow et al., 2020).

Slack / Private Message Drop, p.214 · original PDF · in context

This important study raises the possibility that a novel betacoronavirus(es) related to SARS-CoV and SARS-CoV-2 is present in African bats.To investigate possible exposure to betacoronavirus proteins in Africans we tested plasma and serum samples collected before the reporting of the first Chinese COVID-19 cases in late 2019 for the presence of antibodies that bind to SARS-CoV-2 nucleoprotein, spike or receptor binding domain (RBD).

Slack / Private Message Drop, p.214 · original PDF · in context

The HexaPro Spike and RBD were further purified by size-exclusionchromatography.

Slack / Private Message Drop, p.214 · original PDF · in context

Significant numbers of positive ELISA reactivities to SARS-CoV-2 N, S and RBD were observed in serum and plasma samples from the Ebola survivor cohort.

Slack / Private Message Drop, p.214 · original PDF · in context

As expected there was a correlation between reactivities to trimericS and RBD (p < .0001).

Slack / Private Message Drop, p.214 · original PDF · in context

Significant correlations were also observed between the reactivities to N and S (P=.003)or N and RBD (p < .0001).

Slack / Private Message Drop, p.214 · original PDF · in context

Using conservative cutoffs, 43% of samples (83/192) were positive for reactivity toeither the SARS-CoV-2 N and/or the RBD. 33/192 were reactive to both N and RBD, 19/192 were reactive to N only and 31/192 were reactive to RBD only.

Slack / Private Message Drop, p.214 · original PDF · in context

Scientists such as Lipkin and this Anderson, as well as such scientists as Malik, PanLiewen, Cao Wuchun, Chen Wei, Chen Fang, Shi Zhengli, etc., show the degeneration of human nature, the loss and sorrow of the scientific spirit.

Slack / Private Message Drop, p.219 · original PDF · in context

Beyond the accusations that the bat and pangolin sequences are fraudulent is the whole FCS is a :unicorn_face: BSand that no one has ever seen a FCS generated that way before.

Slack / Private Message Drop, p.234 · original PDF · in context

Earlier cases in Wuhan would not be all that much of a surprise (of course that was predicted in Proximal Origins).

Slack / Private Message Drop, p.247 · original PDF · in context

BTW - The other guest with the BL inspector was David Tully who VR has been supporting via TWiV in a long-standing but lesser known than the MMR war against Lancet over some chronic fatigue/ME papers.

Slack / Private Message Drop, p.257 · original PDF · in context

As if on cue - this evening - Chan trying and failing to make a point about Yan, "Yan did not have a smoking gun for lab origins.

Slack / Private Message Drop, p.277 · original PDF · in context

Amateur aerobiologists: saRESPIRATORYsv-CoV-2 is NOT airborne [just wash you hands, masks don't work]. 2. amateur epidemiologists: Don't worry about social distancing [just wash your hands]. 3.

Slack / Private Message Drop, p.279 · original PDF · in context

In addition, they completely fail to note that it was Clare that suggested Nature Medicine!!

Slack / Private Message Drop, p.279 · original PDF · in context

Tommy has 6 SARS-CoV-2 sero-positive pangolins that are currently being metagenomically sequenced.

Slack / Private Message Drop, p.280 · original PDF · in context

*11 November 2020* Editor's Note: Readers are alerted that concerns have been raised about the identity of the pangolin samples reported in this paper and their relationship to previously published pangolin samples.

Slack / Private Message Drop, p.280 · original PDF · in context

The second Eddie quote also pertinent in light of Xiao et al.editors note *11 November 2020* Editor's Note: Readers are alerted that concerns have been raised about the identity of the pangolin samples reported in this paper and their relationship to previously published pangolin samples.

Slack / Private Message Drop, p.280 · original PDF · in context

The N rxty has held up [the Spike/RBDmostly did not], but more complicated.

Slack / Private Message Drop, p.280 · original PDF · in context

Yes indeed - for me the GD pango RBD is game-over/mic drop for natural origin of SC2, No way the pango RBD was selected in cell culture via passage of a bat cov.

Slack / Private Message Drop, p.280 · original PDF · in context

Alex mentioned Trevor, Relman and others that are pushing back on conventional wisdom and natural origins.

Slack / Private Message Drop, p.290 · original PDF · in context

And being that not only are all my old contacts at NSA already looking into this, but I grew up in the DC area and have loads of contacts in other parts of the government who are all looped in too, and very intently watching who's helping the CPP cover-up their accidental release of what's effectively abio-weapon.I'm only contacting you, like I have Peter Daszak and others, so that during your sentencing phrase you won't beable to plead ignorance to your part in this.

Slack / Private Message Drop, p.294 · original PDF · in context

Hopefully this will be used as a teaching moment - that SC2 is mostly a respiratory virus and that masks and socialdistancing are the best way to prevent spread.

Slack / Private Message Drop, p.308 · original PDF · in context

Come to think of it - scanned pdfs are usually how NIH responds to FOIA requests.

Slack / Private Message Drop, p.314 · original PDF · in context

I've had FOIA request where most of the pages were redacted inblack.

Slack / Private Message Drop, p.314 · original PDF · in context

Under the FOIA and the FCC's implementing rules, you are allowed to obtain copies of FCC records unless the records contain information that is exempt under the FOIA from mandatory disclosure.

Slack / Private Message Drop, p.314 · original PDF · in context

So - here are Daszak's emails including those to Baric. https://usrtk.org/wp-content/uploads/2020/11/Biohazard_FOIA_Maryland_Emails_11.6.20.pdfMost intersting part to me was that at some point Baric dropped out as one of the signatories.

Slack / Private Message Drop, p.316 · original PDF · in context

Another point is that I've seen a lot of pics of the WIV krewe and others climbing down in the caves.

Slack / Private Message Drop, p.324 · original PDF · in context

One think for sure is that there is considerable plasticity in the RBD-ACE2 interactons.

Slack / Private Message Drop, p.327 · original PDF · in context

More importantly it clear that *both* NTD and the RBD need toundergo dramatic shifts that are driven by ACE2 binding to accommodate the S1/S2 and S2' cleavages and ultimately the large scale rearrangement of S2 into the 6 helix bundle.

Slack / Private Message Drop, p.327 · original PDF · in context

At the point you wont really know if vaccinees are protected from the elephant until you fail to see infections in vaccinees.

Slack / Private Message Drop, p.331 · original PDF · in context

Just to revisit Baric https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081895/ "Second, residue 501 in 2019-nCoV RBD (corresponding to residue 487 in SARS-CoV) is an asparagine.

Slack / Private Message Drop, p.333 · original PDF · in context

https://www.propublica.org/article/here-are-six-accidents-unc-researchers-had-with-lab-created-coronaviruses"*April2020*: A UNC scientist underwent 14 days of self-quarantine at home after a mouse bite caused potential exposureto a strain of SARS-CoV-2, the virus that causes COVID-19, that had been adapted for growth in mice.

Slack / Private Message Drop, p.335 · original PDF · in context

Ron Fouchier via second hand quotes [who was most vocal that PO1 should not even mention lab origins] doesn't come off all that great either. https://www.virology.ws/2012/07/10/origin-of-the-h5n1-storm/

Slack / Private Message Drop, p.337 · original PDF · in context

The pattern of prolines in SC1 and SC2 RBDs are distinct - look at PO1 - which creates a very different interaction with ACE2 - but we're seeing in real time the adaptation of SC2 to receptors in humans, minks and mice pretty muchas you'd draw it up.

Slack / Private Message Drop, p.339 · original PDF · in context

Two RBD residues (residues 479 and 487) had to mutate to enable civet SC1 (the 99+% virus) to jump to humans.

Slack / Private Message Drop, p.340 · original PDF · in context

The two SC1 residues are equivalent in how they interact with ACE2 to to SC2 RBD residues Q493 and N501.

Slack / Private Message Drop, p.340 · original PDF · in context

There are other mutations in the elephants that also involve RBD residues, including a Q493K mutant on the Mass patient SC2 that may be due to the fact that he was treated with Regeneron Mabs.

Slack / Private Message Drop, p.341 · original PDF · in context

Th other RBD residues are either immune escape/enhanced ACE2 binders or both.

Slack / Private Message Drop, p.341 · original PDF · in context

However, nature is not so kind and I do believe that we need to actpreemptively with additional CoV vaccines.

Slack / Private Message Drop, p.343 · original PDF · in context

The nucleotide and protein database in PubMed is not working well today :rage: for whatever reason, but of the few cat SC2 sequencesit is said that there are not changes in the RBD of the SC2 in cats.

Slack / Private Message Drop, p.344 · original PDF · in context

According to the authors: "S H655Y isnear the polybasic cleavage site, residin between the receptor binding domain and the fusion peptide, and is thoughtto modulate Spike glycoprotein fusion efficiency 55,56,59 262 .

Slack / Private Message Drop, p.344 · original PDF · in context

@Eddie Holmes It's the GD pangolin - there's that little bit in the RBD where the pangolin blue line is above the green RaTG13 line in Spike.

Slack / Private Message Drop, p.349 · original PDF · in context

The pathogenic motif was not found in any constructed or modified coronavirus associated with Dr.

Slack / Private Message Drop, p.357 · original PDF · in context

He lived in China for many years and is married to a Chinese physician.

Slack / Private Message Drop, p.358 · original PDF · in context

Yes - will be important to repeat what Jesse has done with plasma from vaccinees and to put some of the mutationsin the RBD in in combination.

Slack / Private Message Drop, p.360 · original PDF · in context

You have to believe that they were tuning this particular virus up by passaging in cell culture and/or inserting the FCS, when theyinadvertently released it on the world through a lab accident.

Slack / Private Message Drop, p.361 · original PDF · in context

H being a positive charge in the P5 position is an upgrade to the furin site from P. https://journals.sagepub.com/doi/full/10.4137/BCI.S2049

Slack / Private Message Drop, p.369 · original PDF · in context

The only thing that is going to stop this in the US is vaccine for the reasons you mention.

Slack / Private Message Drop, p.372 · original PDF · in context

One has to hope that despite the variants the vaccines retain enough efficacy to blunt the spread [i'm hopeful but not convinced] and that somehow all stopspulled out they can be manufactured in sufficient quantity and distributed to enough people who agree to bevaccinated.

Slack / Private Message Drop, p.372 · original PDF · in context

And I agree they are going todominate before the vaccines will even start to have any effect on spread.

Slack / Private Message Drop, p.373 · original PDF · in context

The next data point that's going to be super critical is IF we start to see vaccine breakthrough with the UK variant.

Slack / Private Message Drop, p.373 · original PDF · in context

Students are coming back to Tulane campus - there is an almost desperate attempt to get one of the vaccine manufacturers to vaccinate all or at least part of the undergraduate students for the purposes of doing an vaccine efficacy study.

Slack / Private Message Drop, p.374 · original PDF · in context

Faculty, staff, med students, residents and grad students are getting the Pfizer vaccine next week.

Slack / Private Message Drop, p.374 · original PDF · in context

Need to get to work on the v2.0 vaccine as well... the good news is the main variants that pop are now evident.

Slack / Private Message Drop, p.376 · original PDF · in context

Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry.

Slack / Private Message Drop, p.380 · original PDF · in context

This interview does not change my mind that this is going to be very superficial.

Slack / Private Message Drop, p.387 · original PDF · in context

You can bet I'll be using my plasma for some vaccine escape studies....

Slack / Private Message Drop, p.387 · original PDF · in context

PERFECT comment @Andrew Rambaut @Kristian Andersen will know that I appreciate it very much!

Slack / Private Message Drop, p.389 · original PDF · in context

Speaking of Pangos/RatG13 the more I look at the SC2/RatG13 alignment the more I realize Boni/Rambaut were totally spot on, No need to evoke Pango recombination to generate the RBD of SC2.

Slack / Private Message Drop, p.394 · original PDF · in context

YeaH do think there will be failures for the vaccines that don't use a stabilized spike.

Slack / Private Message Drop, p.400 · original PDF · in context

Fortunately the NIH people were on to this for Moderna and Pfizer.

Slack / Private Message Drop, p.401 · original PDF · in context

People (even Tony sorta ) have said expect better immunity from the vaccines.

Slack / Private Message Drop, p.401 · original PDF · in context

We are doing the grand experiments right now with the different vaccines - we.

Slack / Private Message Drop, p.401 · original PDF · in context

NL63 - some similar in the RBD which I did not expect - will take a further look -

Slack / Private Message Drop, p.401 · original PDF · in context

Use *naïveté* in a sentence: It is the height of *naïveté* to claim that one can infer the evolutionary origins of the RmYN02 S1/S2 cleavage site by performing a simple nucleotide alignment as advanced by some proponents of the lab origin hypothesis [1]. 1.

Slack / Private Message Drop, p.402 · original PDF · in context

Proposed author list is a reverse of PO1 with delBL and addition of ProfBill [for fun] and a couple ofstudents who contributed to the Vero passage.

Slack / Private Message Drop, p.404 · original PDF · in context

She's clearly outof her depth in evolutionary biology of viruses, and despite the fact she is Chinese has no special expertise ininternational politics involving China.

Slack / Private Message Drop, p.409 · original PDF · in context

That's a good analogy to flu - and you're right vaccine update will be needed.

Slack / Private Message Drop, p.415 · original PDF · in context

YES - the key message now has to be that the vaccines are NOT going to do it all.

Slack / Private Message Drop, p.418 · original PDF · in context

Indeed, Bannon may be advised not to accept the pardon because it is prima facia evidence that he committed a crime.

Slack / Private Message Drop, p.430 · original PDF · in context

The New Pango Cambobat CoV plus the new Yunnan Bat CoVs looks to melike it will -or at least should - lay to rest the notion that RaTG13, RmYN02, pango CoVs (GD, GX ) were some sortof elaborate fake genome dump hastily contrived in the weeks after the first SC2 cases emerged to cover up the accidental or deliberated release of the GOF/bioweapons research at WIV.

Slack / Private Message Drop, p.439 · original PDF · in context

Obviously, part of the well-thought out nefarious plan by the CCP red army, WIV supervillain virologists and their space alien advisors from the future to release a virus with suboptimal FCS/RBD that they projected would evolve (after it left China) into the more fit/immunologically inert variants currently spreading around the world.

Slack / Private Message Drop, p.440 · original PDF · in context

Don't think this is classified, but I heard from a good source that B.1.351 is in Kuwait.

Slack / Private Message Drop, p.441 · original PDF · in context

Cambobatcov spike pretty interesting - it has the E484 and 5/6 of the GD Pango/SC2 RBD residues we highlighted in PO1.

Slack / Private Message Drop, p.449 · original PDF · in context

Take homes: Thai Bat spike and RmYN02 spike are nearly identical, including at the S1/S2 cleavage site.

Slack / Private Message Drop, p.455 · original PDF · in context

Cambobatcov RBD is very similar to PangoGD RBD and SARS-CoV-2 RBD. 5/6 pf the PO1 key residues.

Slack / Private Message Drop, p.455 · original PDF · in context

Behold: https://www.nbcnews.com/now/video/questions-rise-after-chinese-database-with-covid-research-removed-f or-security-reasons-100059205726 Like the B.1.351 serology, the WHO mission playing out worse than I thought it would.

Slack / Private Message Drop, p.459 · original PDF · in context

J&J : "In the U.S., the vaccine had an efficacy rate of 72 percent in clinical trials.

Slack / Private Message Drop, p.462 · original PDF · in context

Apparently they are off to interview and in studio PANEL:• Jason Yat Sen Li• Prof Mary-Louise McLaws - UNSW and advisor to the WHO• Prof Bates Gill - Professor with the Department of Security Studies at Macquarie University• Professor Raina MacIntyre - Global Biosecurity and head of biosecurity program at Kirby Institute• Professor Nikolai Petrovsky - Medicine Flinders University

Slack / Private Message Drop, p.463 · original PDF · in context

The differences in nucleotide and amino acid trees in spike and RBD seem to have attracted some attention, which is good.

Slack / Private Message Drop, p.464 · original PDF · in context

@Eddie Holmes The HA379 and RmYN02 similarity is after the NTD and into the RBD - INTERESTING!

Slack / Private Message Drop, p.471 · original PDF · in context

Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG.

Slack / Private Message Drop, p.474 · original PDF · in context

Still may need some tweaking (just like the COVID vaccines). [shared file(s): image.png]

Slack / Private Message Drop, p.478 · original PDF · in context

Doug and the VoC that have followed show that SC2 and its RBD and FCS are still adapting to us.

Slack / Private Message Drop, p.491 · original PDF · in context

A lab origin of SC2 is possible *ONLY IF WIV ALREADY* had SC2 or a virus 99% similar to SC2.

Slack / Private Message Drop, p.493 · original PDF · in context

Stated another way- the only way SC2 is a product of GOF research is if WIV had preSC2 aka the 99% progenitor already.

Slack / Private Message Drop, p.493 · original PDF · in context