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Slack / Private Message Drop, pp.474-475 [SLACK_000688] · slack_pm:msg:04929

Page text: p.474, p.475 · original PDF

Date
2021-02-02 15:16
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Intelligence community assessments

Recipients on this medium are inferred from channel membership, not per-message addressing.

AndreW mutations would be among the rarest of all. You might ask why. Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG. For AndreW - You need to change the first two bases of an Alanine codon GCU, GCC, GCA, or GCG and generally all three. But, you really need to want to put in the tryptophan codon UGG because close relatives UAG and UGA are stop codons. Stop codons in viral proteins are bad. If that region mutates "slightly" it's a stop and a dead virus. That's what makes this sequence: WPWYIW which happens to be prior to the SC2 TM domain special too.

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StatementGradeAttributionStance
Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG. own voice, substantive speaker_own asserts

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  1. 2021-02-02 15:16 Robert F. Garry
    AndreW mutations would be among the rarest of all. You might ask why. Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG. For AndreW - You need to change the first two bases of an Alanine codon GCU, GCC, GCA, or GCG and generally all three. But, you really need to want to put in the tryptophan codon UGG because close relatives UAG and UGA are stop codons. Stop codons in viral proteins are bad. If that region mutates "slightly" it's a stop and a dead virus. That's what makes this sequence: WPWYIW which happens to be prior to the SC2 TM domain special too.
  2. 2021-02-02 15:19 Andrew Rambaut open
    Although interestingly the D3L mutation in N in B.1.1.7 is a complete codon change GAT->CTA
  3. 2021-02-02 15:20 Andrew Rambaut open
    As @Kristian Andersen said - this virus is weird
  4. 2021-02-02 15:23 Robert F. Garry open
    Fascinating - I dunno, but short copy-choice error events - 3, 6, 9, 12 bases at a time?
  5. 2021-02-02 16:00 Robert F. Garry open
    Only in New Orleans: https://www.bing.com/videos/search?q=3+6+9+the+monkey+drank+wine&view=detail&a mp;mid=36[...]4N1480D022419AA6B84BBD86%26form%3dCONBDF%26conlogo%3dCT3210127

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