Chat message

Slack / Private Message Drop, p.349 [SLACK_000563] · slack_pm:msg:03672

Date: 2020-12-31 06:29
Type: chat message · slack
mentioned: Edward C. Holmes
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Natural origin / zoonotic spillover Furin cleavage site and molecular features

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@Eddie Holmes It's the GD pangolin - there's that little bit in the RBD where the pangolin blue line is above the green RaTG13 line in Spike. Not as well resolved as in Lam2020, which threw me off, but I guess that's a windowthing. Will be fascinating to see which bat CoV spike the new Cambodian CoV spike lines up with. Biggest deal stillto me similarity with the RaTG13 in orf1b.

Extracted statements

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Statement	Grade	Attribution	Stance
@Eddie Holmes It's the GD pangolin - there's that little bit in the RBD where the pangolin blue line is above the green RaTG13 line in Spike.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

@Eddie Holmes It's the GD pangolin - there's that little bit in the RBD where the pangolin blue line is above the green RaTG13 line in Spike.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-31 06:29 Robert F. Garry

@Eddie Holmes It's the GD pangolin - there's that little bit in the RBD where the pangolin blue line is above the green RaTG13 line in Spike. Not as well resolved as in Lam2020, which threw me off, but I guess that's a windowthing. Will be fascinating to see which bat CoV spike the new Cambodian CoV spike lines up with. Biggest deal stillto me similarity with the RaTG13 in orf1b.
2020-12-31 07:10 Kristian G. Andersen open

I'm not sure "excited" is the right word - "exhausted" might be more fitting :stuck_out_tongue_winking_eye:. I'm sure all the UK folks must be rolling their eyes - "seriously, the US goes nuts over A SINGLE SEQUENCE?! Really". But yeah P681H is very interesting indeed - and yes, only knocks out one predicted site. Separately, I don't know what to do about B.1.1.7. Surges in the US typically have Rt ~1.2, while declines are Rt~0.8. It seems pretty clear that Rt for B.1.1.7 may be increased by roughly 50% (at least in whatever context it finds itself in in the UK) soooo :chart_with_upwards_trend:
2020-12-31 07:11 Andrew Rambaut open

The way I see it is that the US is a test of the hypothesis of 50% greater inherent R.
2020-12-31 07:12 Andrew Rambaut open

If it doesn't take off in the US then it probably isn't
2020-12-31 07:12 Kristian G. Andersen open

Yup. We'll know within a month or two.... Helix got three from San Diego too, so we might be ground zero

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