Professor of Epidemiology, UNC Chapel Hill
| Authored | 561 |
| Substantive (25+ words) | 180 |
| Threads posted in | 2 |
| Distinct active days | 3 |
| Words authored | 16,724 |
| Received (incl. group broadcast) | 601 |
Received counts include every message sent to a channel this person belonged to. That measures presence, not participation.
115 sentences were extracted and attributed to this person. Most are not their own opinion. Reporting the total as “115 statements” would misrepresent them.
| Person | Medium | Msgs | Span |
|---|---|---|---|
| Christina Salazar | interview | 1,104 | 2026-04-10 – 2026-04-10 |
| David T. Lambeth III | interview | 574 | 2026-04-10 – 2026-04-10 |
| Harry Kazenoff | interview | 574 | 2026-04-10 – 2026-04-10 |
| William Henderson | interview | 571 | 2026-04-10 – 2026-04-10 |
| Clark Ervin | interview | 568 | 2026-04-10 – 2026-04-10 |
| Jake Greenberg | interview | 560 | 2026-04-10 – 2026-04-10 |
| Amy C Sims | 2 | 2013-07-29 – 2013-08-23 | |
| Fang Li HR | 1 | 2018-10-24 – 2018-10-24 |
Showing: own voice, substantive needs context quoted / not their view all
He told me he'd worked extensively with people in China during the 20- -- I didn't ask him details DC.Scheduling@LexitasLegal.com about whether it was with Wuhan Institute of Virology or not.
Baric Transcribed Interview (Redacted), p.23 · original PDF · in context
I know those emails have been FOIA'd multiple times, and it says exactly when I was supposed to meet them and where.
Baric Transcribed Interview (Redacted), p.26 · original PDF · in context
It would be a specialized series of documents associated with P3CO review.
Baric Transcribed Interview (Redacted), p.29 · original PDF · in context
One way was that if a grant was submitted that had the potential for gain-of-function research it would be reviewed before they funded it.
Baric Transcribed Interview (Redacted), p.30 · original PDF · in context
So accidental release would have fallen under the category of natural evolutionary processes in cell culture.
Baric Transcribed Interview (Redacted), p.58 · original PDF · in context
I recall that people challenged the idea that it could be a lab leak.
Baric Transcribed Interview (Redacted), p.67 · original PDF · in context
If you have that and it doesn't DC.Scheduling@LexitasLegal.com have a furin cleavage site, you could drop in a cleavage site, using that clone.
Baric Transcribed Interview (Redacted), p.82 · original PDF · in context
So I don't imagine that that would be included in any pan-beta coronavirus vaccine.
Baric Transcribed Interview (Redacted), p.84 · original PDF · in context
If we found the sarbecovirus with a furin cleavage site it would be dropped into a pseudovirus, and its biological characteristics evaluated by the Chinese.
Baric Transcribed Interview (Redacted), p.92 · original PDF · in context
If they were doing it in Michigan, what they were doing were pilot experiments to see if the approach, especially the double-stranded RNA approach, reduced virus titers for North American strains.
Baric Transcribed Interview (Redacted), p.97 · original PDF · in context
The other approach was that having identified strains of viruses that had spike genes that could infect human cells and potentially cause human disease, those spike genes would be isolated and placed in virus vaccine vectors that would then be delivered to the bats in the cave, is the second approach.
Baric Transcribed Interview (Redacted), p.99 · original PDF · in context
As soon as we made full molecular clones, or chimeras, they were done in a WIV backbone, which meant that they're putting a zoonotic spike into a zoonotic strain, to eventually identify vaccine formulations that would be used in the cave, that's not subject to gain-of-function.
Baric Transcribed Interview (Redacted), p.101 · original PDF · in context
And in the grant in the very beginning it says that's not subject to gain-of-function.
Baric Transcribed Interview (Redacted), p.101 · original PDF · in context
That is definitely gain-of-function and would have to be reviewed before anything else was done.
Baric Transcribed Interview (Redacted), p.101 · original PDF · in context
After that paper, it said that there are threat viruses, followed by the WIV1 paper, that said there are threat viruses in nature, in bats, that can have the potential to cause serious human disease.
Baric Transcribed Interview (Redacted), p.102 · original PDF · in context
A good example of this is there are strains that use the DPP4, no, let's say the ACE2 receptor of SARS coronavirus, and you put them in K18 mice that overexpress that ACE2 molecule, you can find genome equivalents but no live virus.
Baric Transcribed Interview (Redacted), p.102 · original PDF · in context
If the furin cleavage site is driving a massive disease phenotype, then that results in a judgment question about whether you would do the next experiment.
Baric Transcribed Interview (Redacted), p.103 · original PDF · in context
So that's one example of where we specifically did not provide a sequence until after the pandemic started, when several researchers wrote Nature Medicine and said, "We want to look at the sequence to determine whether it's the cause of the pandemic."
Baric Transcribed Interview (Redacted), p.123 · original PDF · in context
Yeah, I think maybe we should take a second and review the furin cleavage site, because you seem to think it is the critical event that drove SARS-2 to be pathogenic.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
So in the coronavirus literature, furin cleavage sites have a mixed history.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
So in feline enteric coronavirus, if that virus has a furin cleavage site it's DC.Scheduling@LexitasLegal.com asymptomatic.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
It's when you lose the furin cleavage site that it becomes a fulminant, deadly disease that is 100 percent fatal in cats.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
In mouse hepatitis virus, a couple of researchers had removed the furin cleavage site and said what happens to the pathogenesis?
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
Another group, taking pseudoviruses, had introduced furin sites into the SARS-coronavirus 2003 strain, and the only thing they found was slightly increased infectivity.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
Nothing that said "eureka." So now let's compare SARS from 2003 and SARS-2, and let's ask the question, what experiments were done to prove that the furin cleavage site drove severe disease in SAR-2 pathogenesis.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
The only way to really prove it is to take a virus that doesn't have a furin cleavage site and stick it in.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context
I can make the argument in this room, and I can argue it in front of scientists, that the introduction of the furin cleavage site in SARS-2 attenuated its pathogenesis and increased its transmissibility, and that was to its benefit.
Baric Transcribed Interview (Redacted), p.131 · original PDF · in context