Transcript segment

Baric Transcribed Interview (Redacted), pp.103-104 · baric_ti:utt:00887

Date: 2026-04-10 09:00 (day precision)
Type: transcript segment · interview
recipient: Christina Salazar, Harry Kazenoff, David T. Lambeth III, William Henderson, Clark Ervin, Jake Greenberg
speaker: Ralph S. Baric
Topics: Furin cleavage site and molecular features

It would depend on the outcomes of all the earlier experiments, right. So remember, one of those DC.Scheduling@LexitasLegal.com experiments was to take the virus that had the furin cleavage site in it, resurrect that virus, put it in animals, see what the effect was. Remove the furin cleavage site, see what the effect was. If the furin cleavage site is driving a massive disease phenotype, then that results in a judgment question about whether you would do the next experiment. And it also would then demand the importance of having it reviewed before you proceeded.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
So remember, one of those DC.Scheduling@LexitasLegal.com experiments was to take the virus that had the furin cleavage site in it, resurrect that virus, put it in animals, see what the effect was.	own voice, substantive	speaker_own	asserts
Remove the furin cleavage site, see what the effect was.	needs context	speaker_own	asserts
If the furin cleavage site is driving a massive disease phenotype, then that results in a judgment question about whether you would do the next experiment.	quoted / not their view	hypothetical conditional framing	asserts

Statement

Grade

Attribution

Stance

So remember, one of those DC.Scheduling@LexitasLegal.com experiments was to take the virus that had the furin cleavage site in it, resurrect that virus, put it in animals, see what the effect was.

own voice, substantive

speaker_own

asserts

Remove the furin cleavage site, see what the effect was.

needs context

speaker_own

asserts

If the furin cleavage site is driving a massive disease phenotype, then that results in a judgment question about whether you would do the next experiment.

quoted / not their view

hypothetical conditional framing

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2026-04-10 09:00 Ralph S. Baric open

Yes.
2026-04-10 09:00 Christina Salazar open

-- is that gain-of-function?
2026-04-10 09:00 Ralph S. Baric open

Um --
2026-04-10 09:00 Christina Salazar open

Because do you know what is --
2026-04-10 09:00 Ralph S. Baric

It would depend on the outcomes of all the earlier experiments, right. So remember, one of those DC.Scheduling@LexitasLegal.com experiments was to take the virus that had the furin cleavage site in it, resurrect that virus, put it in animals, see what the effect was. Remove the furin cleavage site, see what the effect was. If the furin cleavage site is driving a massive disease phenotype, then that results in a judgment question about whether you would do the next experiment. And it also would then demand the importance of having it reviewed before you proceeded.
2026-04-10 09:00 Christina Salazar open

Okay.
2026-04-10 09:00 Ralph S. Baric open

Before you proceed.
2026-04-10 09:00 Christina Salazar open

So are you saying that we can never say whether a grant proposal was proposing to do gain-of13 function until we get all the way up to the point where you actually almost do it?
2026-04-10 09:00 Ralph S. Baric open

No. I'm saying in the context of a grant proposal where the agency asks you specifically to learn, down to the nucleotide level, what causes the phenotype, yes, you do all those experiments.

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