Slack / Private Message Drop — page 400

Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117! (they're epidemiologically connected...). [2021-01-14 16:14:25] [Andrew Rambaut] How long after vaccination? [2021-01-14 16:17:22] [Kristian Andersen] I believe this was just after receiving second shots - but importantly, in the presence of strong IgG anti-S titers. [2021-01-14 16:18:08] [Kristian Andersen] Don't know if these titers are neuts though - something we need to test. We have a bunch inbound from Jordan too, but those are failures from one of the Chinese vaccines. [2021-01-14 16:23:12] [Andrew Rambaut] All vaccine failures in the UK will automatically go for sequencing - I am hopeful we will be told which ones they are but who knows. [2021-01-14 16:24:30] [Kristian Andersen] Yeah, going to be really important over the next couple of months to understand what's going on here. The immunologists seem very (VERY!) sure there is no problem with the UK/RSA/Brazil lineages when it comes to immunity. I'm less certain. [2021-01-14 16:26:40] [Andrew Rambaut] I agree. If these constellations have no effect on vaccine elicited immunity then boy will we have dodged a bullet. [2021-01-14 16:27:26] [Kristian Andersen] I'm almost certain they'll have _some_ effect on efficacy, but just not sure how much. Let's hope very little (say, 95% > 92%...) [2021-01-14 16:27:58] [Kristian Andersen] Lord knows what the effectiveness is going to be anyway. We'll see... [2021-01-14 16:31:57] [Kristian Andersen] Tangential to this, but important to fully understand just how tolerant SARS-CoV-2 is to mutations in immunologically key sites - HCoV-NL63 uses ACE2 as a receptor too and is very diverged from SC2. @Robert Garry - I don't know if you have looked more closely at that virus going through your alignments / structures? [2021-01-14 16:56:55] [Robert Garry] YeaH do think there will be failures for the vaccines that don't use a stabilized spike. Erica Saphire and others have been preaching this, some folks don't listen. Same with Lassa vaccine, but that's an entirely different story. BTW - I was on call yesterday with Erica/NIH so I missed several Zooms. [2021-01-14 17:02:15] [Kristian Andersen]