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Slack / Private Message Drop, p.400 [SLACK_000614] · slack_pm:msg:04129

Date: 2021-01-14 16:24
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Yeah, going to be really important over the next couple of months to understand what's going on here. The immunologists seem very (VERY!) sure there is no problem with the UK/RSA/Brazil lineages when it comes to immunity. I'm less certain.

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2021-01-14 16:14 Andrew Rambaut open

How long after vaccination?
2021-01-14 16:17 Kristian G. Andersen open

I believe this was just after receiving second shots - but importantly, in the presence of strong IgG anti-S titers.
2021-01-14 16:18 Kristian G. Andersen open

Don't know if these titers are neuts though - something we need to test. We have a bunch inbound from Jordan too, but those are failures from one of the Chinese vaccines.
2021-01-14 16:23 Andrew Rambaut open

All vaccine failures in the UK will automatically go for sequencing - I am hopeful we will be told which ones they are but who knows.
2021-01-14 16:24 Kristian G. Andersen

Yeah, going to be really important over the next couple of months to understand what's going on here. The immunologists seem very (VERY!) sure there is no problem with the UK/RSA/Brazil lineages when it comes to immunity. I'm less certain.
2021-01-14 16:26 Andrew Rambaut open

I agree. If these constellations have no effect on vaccine elicited immunity then boy will we have dodged a bullet.
2021-01-14 16:27 Kristian G. Andersen open

I'm almost certain they'll have _some_ effect on efficacy, but just not sure how much. Let's hope very little (say, 95%> 92%...)
2021-01-14 16:27 Kristian G. Andersen open

Lord knows what the effectiveness is going to be anyway. We'll see...
2021-01-14 16:31 Kristian G. Andersen open

Tangential to this, but important to fully understand just how tolerant SARS-CoV-2 is to mutations in immunologicallykey sites - HCoV-NL63 uses ACE2 as a receptor too and is very diverged from SC2. @Robert Garry - I don't know ifyou have looked more closely at that virus going through your alignments / structures?

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