Slack / Private Message Drop — page 401

Why they did not stabilize that spike I don't know - so simple, people! If we follow this crackpot theory a little bit, knowing that animals that received the OxAZN vaccine were not protected against infection (at all - vaccinated animals had as much virus as unvaccinated animals in the upper airways after challenge). Could the non-stabilized spike lead to a very narrow immune response with very few epitopes exposed, some of which might be suboptimal? If yes, then presumably the virus might be able to escape immunity quite easily by changing a limited set of amino acids - and, presumably, the same/similar set of AAs. We wouldn't see the same happen in natural infections - more complex to escape. We also wouldn't see the same from other vaccines - because, again, more complex. I don't know if this holds up... Seems like a reach to me - albeit, maybe not impossible? [2021-01-14 18:23:14] [Robert Garry] Fortunately the NIH people were on to this for Moderna and Pfizer. Yes - natural infections more likely more polyclonal - not to mention T cell immunity to other viral proteins besides spike. People (even Tony sorta ) have said expect better immunity from the vaccines. I can't really get my head around that although natural infection (no stabilized spike) maybe not the right antibodies. We are doing the grand experiments right now with the different vaccines - we. [2021-01-14 18:23:23] [Robert Garry] will see. [2021-01-14 18:53:16] [Kristian Andersen] [thread - ID: 2021-01-14 18:53:16] Bloody hell - retweeted this earlier, but just got a chance to read the whole thread. She is _such_ a hard hitter. :boxing_glove: https://twitter.com/angie_rasmussen/status/1349754581702508544?s=20 [2021-01-14 20:14:00] [Robert Garry] NL63 - some similar in the RBD which I did not expect - will take a further look - [2021-01-14 23:54:29] [Andrew Rambaut] [thread - ID: 2021-01-14 18:53:16] @Kristian Andersen This reply though: [shared file(s): image.png] [2021-01-14 23:54:56] [Andrew Rambaut] I think Gilles has really nailed it. That's Angela told. [2021-01-15 00:35:07] [Eddie Holmes] I didn't understand the concept either. No idea how I've gotten by so long. [2021-01-15 01:10:30] [Andrew Rambaut] I haven't even bothered to look it up. The umlaut put me off. [2021-01-15 06:27:17] [Robert Garry]