Chat message

Slack / Private Message Drop, pp.399-400 [SLACK_000613] · slack_pm:msg:04124

Date: 2021-01-14 16:06
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

> Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs(we see all of these mutations appear individually many times). Agreed. The way I'm thinking about this is that there must be an initial selection pressure that drives the fixation ofthose mutations - almost certainly, that selection pressure is intrahost. Once that variant is out - and it's more transmissible / able to evade immunity - then it's a different selection pressure driving its fixation in the population. Itoo just think there's a really unfortunate relationship between really fit intrahost, means you're really fit in the larger population. Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117! (they'reepidemiologically connected...).

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117!	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117!

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-14 15:54 Andrew Rambaut open

Nice piece. Angie is a true hero. I can't imagine what she must put up with (you probably can more than me, Eddie, but women get it so much worse).
2021-01-14 15:58 Edward C. Holmes open

She's a 1000X times tougher than me. I find it very difficult and have to get off social media as much as I can. I also hate dealing with the mainstream media. She must get endless shit. No idea how she manages it.
2021-01-14 16:03 Kristian G. Andersen open

Angie is indeed tough as nails - true hero! I *do* wonder if she has a hard time dealing with all the shit she must begetting - she _is_ moving to Canada after all. Can't blame for for leaving this dumpster fire - I'd do the same in aheartbeat if anybody up north wanted me.
2021-01-14 16:04 Edward C. Holmes open

There's an opening at the Wuhan Institute of Virology. Labs were recently renovated and cleaned.
2021-01-14 16:06 Kristian G. Andersen

> Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs(we see all of these mutations appear individually many times). Agreed. The way I'm thinking about this is that there must be an initial selection pressure that drives the fixation ofthose mutations - almost certainly, that selection pressure is intrahost. Once that variant is out - and it's more transmissible / able to evade immunity - then it's a different selection pressure driving its fixation in the population. Itoo just think there's a really unfortunate relationship between really fit intrahost, means you're really fit in the larger population. Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117! (they'reepidemiologically connected...).
2021-01-14 16:14 Andrew Rambaut open

How long after vaccination?
2021-01-14 16:17 Kristian G. Andersen open

I believe this was just after receiving second shots - but importantly, in the presence of strong IgG anti-S titers.
2021-01-14 16:18 Kristian G. Andersen open

Don't know if these titers are neuts though - something we need to test. We have a bunch inbound from Jordan too, but those are failures from one of the Chinese vaccines.
2021-01-14 16:23 Andrew Rambaut open

All vaccine failures in the UK will automatically go for sequencing - I am hopeful we will be told which ones they are but who knows.

Full conversation →