A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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I believe this was just after receiving second shots - but importantly, in the presence of strong IgG anti-S titers.
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Don't know if these titers are neuts though - something we need to test. We have a bunch inbound from Jordan too, but those are failures from one of the Chinese vaccines.
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All vaccine failures in the UK will automatically go for sequencing - I am hopeful we will be told which ones they are but who knows.
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Yeah, going to be really important over the next couple of months to understand what's going on here. The immunologists seem very (VERY!) sure there is no problem with the UK/RSA/Brazil lineages when it comes to immunity. I'm less certain.
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2021-01-14 16:26
Andrew Rambaut
I agree. If these constellations have no effect on vaccine elicited immunity then boy will we have dodged a bullet.
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I'm almost certain they'll have _some_ effect on efficacy, but just not sure how much. Let's hope very little (say, 95%> 92%...)
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Lord knows what the effectiveness is going to be anyway. We'll see...
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Tangential to this, but important to fully understand just how tolerant SARS-CoV-2 is to mutations in immunologicallykey sites - HCoV-NL63 uses ACE2 as a receptor too and is very diverged from SC2. @Robert Garry - I don't know ifyou have looked more closely at that virus going through your alignments / structures?
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YeaH do think there will be failures for the vaccines that don't use a stabilized spike. Erica Saphire and others have been preaching this, some folks don't listen. Same with Lassa vaccine, but that's an entirely different story. BTW - Iwas on call yesterday with Erica/NIH so I missed several Zooms.