Chat message

Slack / Private Message Drop, p.436 [SLACK_000650] · slack_pm:msg:04511

Date: 2021-01-22 11:49
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-22 11:09 Robert F. Garry open

@Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around241-3 in the mink.
2021-01-22 11:12 Kristian G. Andersen open

@Kristian Andersen Yeah. I'm going more with it showing up both in RSA and BRA and the RSA paper showing that the NTD mutations are important for escape.
2021-01-22 11:45 Robert F. Garry open

@Kristian Andersen Yeah - NTD is definitely doing something we are not yet accounting for.
2021-01-22 11:47 Andrew Rambaut open

I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors.
2021-01-22 11:49 Edward C. Holmes

This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]
2021-01-22 11:50 Edward C. Holmes open

From Weifeng and obviously in very strict confidence. I assume these are from Yunnan. Also has some interesting alphas.
2021-01-22 11:54 Kristian G. Andersen open

Oh, very interesting! Looking forward to seeing the actual sequences. Very cool.
2021-01-22 11:57 Edward C. Holmes open

The similarity scores imply that some are as close as RaTG13 in a number of genes. Will be good to see the Cambodian one in this tree as well. Interesting recombination events with respect to the pangolin viruses. Nature isan amazing thing.
2021-01-22 12:13 Kristian G. Andersen open

What's interesting is that it's all over the place every time we find a new virus. We're only scratching 0.000000000000000000000000000000001% of the surface.

Full conversation →