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Slack / Private Message Drop, p.436 [SLACK_000650] · slack_pm:msg:04507

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@Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around241-3 in the mink.

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2021-01-22 11:07 Kristian G. Andersen open

@Andrew Rambaut - how good is the data on the increased mortality from B.1.1.7? Makes sense it would be, however, comparing mortality rates during a surge is problematic....
2021-01-22 11:09 Robert F. Garry

@Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around241-3 in the mink.
2021-01-22 11:12 Kristian G. Andersen open

@Kristian Andersen Yeah. I'm going more with it showing up both in RSA and BRA and the RSA paper showing that the NTD mutations are important for escape.
2021-01-22 11:45 Robert F. Garry open

@Kristian Andersen Yeah - NTD is definitely doing something we are not yet accounting for.
2021-01-22 11:47 Andrew Rambaut open

I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors.
2021-01-22 11:49 Edward C. Holmes open

This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]