Slack / Private Message Drop — page 436

[Kristian Andersen] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen I think L18F is more key than people realize [2021-01-22 09:17:23] [Andrew Rambaut] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen But L18F doesn't explain the RSA results [2021-01-22 09:36:12] [Kristian Andersen] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen ? [2021-01-22 09:59:04] [Kristian Andersen] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen RSA has that one, right? [shared file(s): Screen Shot 2021-01-22 at 09.58.38.png] [2021-01-22 11:07:41] [Kristian Andersen] @Andrew Rambaut - how good is the data on the increased mortality from B.1.1.7? Makes sense it would be, however, comparing mortality rates during a surge is problematic.... [2021-01-22 11:09:28] [Robert Garry] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around 241-3 in the mink. [2021-01-22 11:12:47] [Kristian Andersen] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen Yeah. I'm going more with it showing up both in RSA and BRA and the RSA paper showing that the NTD mutations are important for escape. [2021-01-22 11:45:01] [Robert Garry] [thread - ID: 2021-01-21 15:14:06] @Kristian Andersen Yeah - NTD is definitely doing something we are not yet accounting for. [2021-01-22 11:47:56] [Andrew Rambaut] I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors. [2021-01-22 11:49:13] [Eddie Holmes] This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx] [2021-01-22 11:50:06] [Eddie Holmes]