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Slack / Private Message Drop, p.437 [SLACK_000651] · slack_pm:msg:04514

Date: 2021-01-22 11:57
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Natural origin / zoonotic spillover

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The similarity scores imply that some are as close as RaTG13 in a number of genes. Will be good to see the Cambodian one in this tree as well. Interesting recombination events with respect to the pangolin viruses. Nature isan amazing thing.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-22 11:47 Andrew Rambaut open

I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors.
2021-01-22 11:49 Edward C. Holmes open

This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]
2021-01-22 11:50 Edward C. Holmes open

From Weifeng and obviously in very strict confidence. I assume these are from Yunnan. Also has some interesting alphas.
2021-01-22 11:54 Kristian G. Andersen open

Oh, very interesting! Looking forward to seeing the actual sequences. Very cool.
2021-01-22 11:57 Edward C. Holmes

The similarity scores imply that some are as close as RaTG13 in a number of genes. Will be good to see the Cambodian one in this tree as well. Interesting recombination events with respect to the pangolin viruses. Nature isan amazing thing.
2021-01-22 12:13 Kristian G. Andersen open

What's interesting is that it's all over the place every time we find a new virus. We're only scratching 0.000000000000000000000000000000001% of the surface.
2021-01-22 12:21 Edward C. Holmes open

Exactly. So many viruses in nature that are close to SARS-CoV-2.
2021-01-22 12:21 Edward C. Holmes open

Take a look @Andrew Rambaut and @Robert Garry
2021-01-22 12:24 Robert F. Garry open

Very interesting- how about the S1/S2 junction - HA379_CNSv1 seems close to RmYN02 - Maybe it and perhaps the other have indels there?

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