A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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@Andrew Rambaut - how good is the data on the increased mortality from B.1.1.7? Makes sense it would be, however, comparing mortality rates during a surge is problematic....
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@Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around241-3 in the mink.
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@Kristian Andersen Yeah. I'm going more with it showing up both in RSA and BRA and the RSA paper showing that the NTD mutations are important for escape.
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@Kristian Andersen Yeah - NTD is definitely doing something we are not yet accounting for.
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2021-01-22 11:47
Andrew Rambaut
I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors.
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This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]
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From Weifeng and obviously in very strict confidence. I assume these are from Yunnan. Also has some interesting alphas.
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Oh, very interesting! Looking forward to seeing the actual sequences. Very cool.
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The similarity scores imply that some are as close as RaTG13 in a number of genes. Will be good to see the Cambodian one in this tree as well. Interesting recombination events with respect to the pangolin viruses. Nature isan amazing thing.