Private channel session 852
19 messages over 1h 46m, 2021-01-22 – 2021-01-22.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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@Andrew Rambaut - how good is the data on the increased mortality from B.1.1.7? Makes sense it would be, however, comparing mortality rates during a surge is problematic....
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@Kristian Andersen L18F is not in the cryo structure, but it is likely in the NTD near where delHV and the del around241-3 in the mink.
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@Kristian Andersen Yeah. I'm going more with it showing up both in RSA and BRA and the RSA paper showing that the NTD mutations are important for escape.
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@Kristian Andersen Yeah - NTD is definitely doing something we are not yet accounting for.
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I am not sure it is that strong. But the report was leaked so they had to do the press. It is really hard to tease apart all the confounding factors.
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This largely speaks for itself: [shared file(s): FigXX_B_Beta_MSA_v2.2_RdRp.pdf, FigXX_A_Beta_MSA_v2.2_Full length genome.pdf, all_similarity.xlsx]
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From Weifeng and obviously in very strict confidence. I assume these are from Yunnan. Also has some interesting alphas.
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Oh, very interesting! Looking forward to seeing the actual sequences. Very cool.
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The similarity scores imply that some are as close as RaTG13 in a number of genes. Will be good to see the Cambodian one in this tree as well. Interesting recombination events with respect to the pangolin viruses. Nature isan amazing thing.
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What's interesting is that it's all over the place every time we find a new virus. We're only scratching 0.000000000000000000000000000000001% of the surface.
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Exactly. So many viruses in nature that are close to SARS-CoV-2.
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Take a look @Andrew Rambaut and @Robert Garry
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Very interesting- how about the S1/S2 junction - HA379_CNSv1 seems close to RmYN02 - Maybe it and perhaps the other have indels there?
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@Kristian Andersen BTW - nice chart there @Kristian Andersen
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I'll see what I can find out.
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I like the fact that the new ones are filling in some gaps...
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Yes. I'm sure Alina and Yuri will be happy as well.
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I listened a bit to the Yuri and Billy show live this morning - if they mentioned the new virological post I did not hear it.They were however very much trying to project the airs of serious scientists - no pictures of male genitalia. In thismode neither could be described as stupid per se, just some really misguided, misinformed and biased opinionsmasked up as "science." Yeah Yuri is a fraudster.
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Yeah Alina read our post too. [shared file(s): image.png]