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Slack / Private Message Drop, p.399 [SLACK_000613] · slack_pm:msg:04123

Page text: p.399 · original PDF

Date
2021-01-14 16:04
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes
Topics
Wuhan Institute of Virology collaboration

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There's an opening at the Wuhan Institute of Virology. Labs were recently renovated and cleaned.

In context

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  1. 2021-01-14 15:47 Edward C. Holmes open
    Indeed. Not saying the theory is wrong, just that there are some loose ends. I can only imagine how Alina and ganghave reacted to this: [shared file(s): s41591-020-01205-5.pdf]
  2. 2021-01-14 15:54 Andrew Rambaut open
    Nice piece. Angie is a true hero. I can't imagine what she must put up with (you probably can more than me, Eddie, but women get it so much worse).
  3. 2021-01-14 15:58 Edward C. Holmes open
    She's a 1000X times tougher than me. I find it very difficult and have to get off social media as much as I can. I also hate dealing with the mainstream media. She must get endless shit. No idea how she manages it.
  4. 2021-01-14 16:03 Kristian G. Andersen open
    Angie is indeed tough as nails - true hero! I *do* wonder if she has a hard time dealing with all the shit she must begetting - she _is_ moving to Canada after all. Can't blame for for leaving this dumpster fire - I'd do the same in aheartbeat if anybody up north wanted me.
  5. 2021-01-14 16:04 Edward C. Holmes
    There's an opening at the Wuhan Institute of Virology. Labs were recently renovated and cleaned.
  6. 2021-01-14 16:06 Kristian G. Andersen open
    > Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs(we see all of these mutations appear individually many times). Agreed. The way I'm thinking about this is that there must be an initial selection pressure that drives the fixation ofthose mutations - almost certainly, that selection pressure is intrahost. Once that variant is out - and it's more transmissible / able to evade immunity - then it's a different selection pressure driving its fixation in the population. Itoo just think there's a really unfortunate relationship between really fit intrahost, means you're really fit in the larger population. Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117! (they'reepidemiologically connected...).
  7. 2021-01-14 16:14 Andrew Rambaut open
    How long after vaccination?
  8. 2021-01-14 16:17 Kristian G. Andersen open
    I believe this was just after receiving second shots - but importantly, in the presence of strong IgG anti-S titers.
  9. 2021-01-14 16:18 Kristian G. Andersen open
    Don't know if these titers are neuts though - something we need to test. We have a bunch inbound from Jordan too, but those are failures from one of the Chinese vaccines.

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