A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
-
Given the low frequency of chronic infections compared to the huge number with 'normal' durations of infection, doesn't the fact that we are seeing the same sort of constellation of mutations evolve and spread 3 times independently suggest that they have a major advantage at the population level?
-
Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs (wesee all of these mutations appear individually many times).
-
So the chronic infections offer an opportunity for these to arise in combination. Chronic infections are rare as aproportion of infections but there are shed loads of infections now.
-
Indeed. Not saying the theory is wrong, just that there are some loose ends. I can only imagine how Alina and ganghave reacted to this: [shared file(s): s41591-020-01205-5.pdf]
-
2021-01-14 15:54
Andrew Rambaut
Nice piece. Angie is a true hero. I can't imagine what she must put up with (you probably can more than me, Eddie, but women get it so much worse).
-
She's a 1000X times tougher than me. I find it very difficult and have to get off social media as much as I can. I also hate dealing with the mainstream media. She must get endless shit. No idea how she manages it.
-
Angie is indeed tough as nails - true hero! I *do* wonder if she has a hard time dealing with all the shit she must begetting - she _is_ moving to Canada after all. Can't blame for for leaving this dumpster fire - I'd do the same in aheartbeat if anybody up north wanted me.
-
There's an opening at the Wuhan Institute of Virology. Labs were recently renovated and cleaned.
-
> Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs(we see all of these mutations appear individually many times). Agreed. The way I'm thinking about this is that there must be an initial selection pressure that drives the fixation ofthose mutations - almost certainly, that selection pressure is intrahost. Once that variant is out - and it's more transmissible / able to evade immunity - then it's a different selection pressure driving its fixation in the population. Itoo just think there's a really unfortunate relationship between really fit intrahost, means you're really fit in the larger population. Separately, two vaccine failures en route to our lab - I sure as shit hope these are not B117! (they'reepidemiologically connected...).