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Slack / Private Message Drop, p.758 [SLACK_000972] · slack_pm:msg:07937

Page text: p.758 · original PDF

Date
2021-05-06 21:21
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

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Yes, I've used this one in talks

In context

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  1. 2021-05-06 20:55 Kristian G. Andersen open
    Yup. Exactly.
  2. 2021-05-06 20:55 Edward C. Holmes open
    First experiment to stick the SC2 RBD in a mouse adapted strain.
  3. 2021-05-06 20:57 Kristian G. Andersen open
    Yeah - very likely, but depends on the purpose of the experiment.
  4. 2021-05-06 21:08 Kristian G. Andersen open
    And just for reference - here are those beautiful feline CoVs with an identical FCS motif. It's out there... [shared file(s): Screen Shot 2021-05-06 at 9.07.11 PM.png]
  5. 2021-05-06 21:21 Edward C. Holmes
    Yes, I've used this one in talks
  6. 2021-05-06 21:21 Kristian G. Andersen open
    Sometimes I fucking love science. One of Wade's biggest arguments is that (and this is an oldie but goodie...) the FCS is strange because it has those two CGG codons coding the arginines. Now, take a look at the Feline CoVs -first R is coded by CGG too. Totally sinks that entire argument. [shared file(s): Screen Shot 2021-05-06 at 9.19.12PM.png]
  7. 2021-05-06 21:22 Edward C. Holmes open
    Perfect!!
  8. 2021-05-06 21:23 Edward C. Holmes open
    Don't you love nature!!
  9. 2021-05-06 21:23 Kristian G. Andersen open
    Looking at the CGG codon itself and how often it's used: Common cold CoVs: 4% SARS: 5% SARS2: 3% SARSrCoVs: 2% Totally sinks the argument.

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