COVID-19 Records

Chat message

Slack / Private Message Drop, p.758 [SLACK_000972] · slack_pm:msg:07941

Page text: p.758 · original PDF

Date
2021-05-06 21:23
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Looking at the CGG codon itself and how often it's used: Common cold CoVs: 4% SARS: 5% SARS2: 3% SARSrCoVs: 2% Totally sinks the argument.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-05-06 21:21 Edward C. Holmes open
    Yes, I've used this one in talks
  2. 2021-05-06 21:21 Kristian G. Andersen open
    Sometimes I fucking love science. One of Wade's biggest arguments is that (and this is an oldie but goodie...) the FCS is strange because it has those two CGG codons coding the arginines. Now, take a look at the Feline CoVs -first R is coded by CGG too. Totally sinks that entire argument. [shared file(s): Screen Shot 2021-05-06 at 9.19.12PM.png]
  3. 2021-05-06 21:22 Edward C. Holmes open
    Perfect!!
  4. 2021-05-06 21:23 Edward C. Holmes open
    Don't you love nature!!
  5. 2021-05-06 21:23 Kristian G. Andersen
    Looking at the CGG codon itself and how often it's used: Common cold CoVs: 4% SARS: 5% SARS2: 3% SARSrCoVs: 2% Totally sinks the argument.
  6. 2021-05-06 21:24 Edward C. Holmes open
    Hilarious!
  7. 2021-05-06 21:25 Kristian G. Andersen open
    And one more - if CGGCGG had been 'strange' in SARS-CoV-2, we would see plenty of synonymous mutations (R has six codons). What do we see if we analyze the ~1.5 million genomes? CGG is found in 99.84% of all sequences at that site. Not exactly unstable. I can go to bed now. I'll spend some time on the rest of his arguments tomorrow. Just because it's fun...
  8. 2021-05-06 21:25 Edward C. Holmes open
    Great job! Get some rest.

Full conversation →