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Slack / Private Message Drop, p.758 [SLACK_000972] · slack_pm:msg:07940

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Don't you love nature!!

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-05-06 21:08 Kristian G. Andersen open

And just for reference - here are those beautiful feline CoVs with an identical FCS motif. It's out there... [shared file(s): Screen Shot 2021-05-06 at 9.07.11 PM.png]
2021-05-06 21:21 Edward C. Holmes open

Yes, I've used this one in talks
2021-05-06 21:21 Kristian G. Andersen open

Sometimes I fucking love science. One of Wade's biggest arguments is that (and this is an oldie but goodie...) the FCS is strange because it has those two CGG codons coding the arginines. Now, take a look at the Feline CoVs -first R is coded by CGG too. Totally sinks that entire argument. [shared file(s): Screen Shot 2021-05-06 at 9.19.12PM.png]
2021-05-06 21:22 Edward C. Holmes open

Perfect!!
2021-05-06 21:23 Edward C. Holmes

Don't you love nature!!
2021-05-06 21:23 Kristian G. Andersen open

Looking at the CGG codon itself and how often it's used: Common cold CoVs: 4% SARS: 5% SARS2: 3% SARSrCoVs: 2% Totally sinks the argument.
2021-05-06 21:24 Edward C. Holmes open

Hilarious!
2021-05-06 21:25 Kristian G. Andersen open

And one more - if CGGCGG had been 'strange' in SARS-CoV-2, we would see plenty of synonymous mutations (R has six codons). What do we see if we analyze the ~1.5 million genomes? CGG is found in 99.84% of all sequences at that site. Not exactly unstable. I can go to bed now. I'll spend some time on the rest of his arguments tomorrow. Just because it's fun...
2021-05-06 21:25 Edward C. Holmes open

Great job! Get some rest.