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Slack / Private Message Drop, p.758 [SLACK_000972] · slack_pm:msg:07935

Page text: p.758 · original PDF

Date
2021-05-06 20:57
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Yeah - very likely, but depends on the purpose of the experiment.

In context

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  1. 2021-05-06 20:42 Kristian G. Andersen open
    Well, this https://www.nature.com/articles/nm.3985
  2. 2021-05-06 20:52 Edward C. Holmes open
    And it shows the key point: you use a standard backbone when you do this GOF work. And surely Shi would have done the same as she collaborated with Baric? And surely she would have asked Baric for advice but there's nothing in his emails?
  3. 2021-05-06 20:55 Kristian G. Andersen open
    Yup. Exactly.
  4. 2021-05-06 20:55 Edward C. Holmes open
    First experiment to stick the SC2 RBD in a mouse adapted strain.
  5. 2021-05-06 20:57 Kristian G. Andersen
    Yeah - very likely, but depends on the purpose of the experiment.
  6. 2021-05-06 21:08 Kristian G. Andersen open
    And just for reference - here are those beautiful feline CoVs with an identical FCS motif. It's out there... [shared file(s): Screen Shot 2021-05-06 at 9.07.11 PM.png]
  7. 2021-05-06 21:21 Edward C. Holmes open
    Yes, I've used this one in talks
  8. 2021-05-06 21:21 Kristian G. Andersen open
    Sometimes I fucking love science. One of Wade's biggest arguments is that (and this is an oldie but goodie...) the FCS is strange because it has those two CGG codons coding the arginines. Now, take a look at the Feline CoVs -first R is coded by CGG too. Totally sinks that entire argument. [shared file(s): Screen Shot 2021-05-06 at 9.19.12PM.png]
  9. 2021-05-06 21:22 Edward C. Holmes open
    Perfect!!

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