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1. 2021-02-14 11:58 Kristian G. Andersen open
   Very interesting figure! [shared file(s): EuNejqhXcAUjMGC.jpeg]
2. 2021-02-14 11:59 Kristian G. Andersen open
   What's wild - two doses of Pfizer leads to greater neutralization against SARS-CoV than B.1.351 according to this figure. That's wild.\
3. 2021-02-14 12:00 Kristian G. Andersen open
   And IMO - highly suggestive of lower overall antigenicity of B.1.351 - i.e., a more general mechanism of (Ab-mediated) immune evasion.
4. 2021-02-14 12:13 Robert F. Garry open
   Kind of surprising to me -P1 takes a hit, but B.1.351 is bad. Does it suggest that the B.1.351 NTD mutations D80A[DorA?). D215G (DouG, Jr?),R246I (RidhI?) may be more problematic than EriK????
5. 2021-02-14 12:15 Kristian G. Andersen
   Yeah, I was really surprised by that difference as well - I thought they'd be about equal. Need to see the preprint itself so we can see the actual mutations
6. 2021-02-14 12:15 Kristian G. Andersen open
   And B.1.351 is just dead dead - it's pretty scary.
7. 2021-02-14 12:37 Robert F. Garry open
   Note that all of those mutations D80A [DorA?). D215G (DouG, Jr?),R246I (RidhI?) remove a charge (aspartic acid orarginine) - if you scroll back to initial discussions of Doug you'll see references that similar D mutations havecharacterized flu mutations in the past.
8. 2021-02-14 12:47 Edward C. Holmes open
   Yes, this is coming along nicely. Great work Bob. Let's try and get this sent this week if we can. It's coming along nicely.
9. 2021-02-14 12:54 Robert F. Garry open
   Will do!

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