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Slack / Private Message Drop, p.515 [SLACK_000729] · slack_pm:msg:05374

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Yes, this is coming along nicely. Great work Bob. Let's try and get this sent this week if we can. It's coming along nicely.

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2021-02-14 12:13 Robert F. Garry open

Kind of surprising to me -P1 takes a hit, but B.1.351 is bad. Does it suggest that the B.1.351 NTD mutations D80A[DorA?). D215G (DouG, Jr?),R246I (RidhI?) may be more problematic than EriK????
2021-02-14 12:15 Kristian G. Andersen open

Yeah, I was really surprised by that difference as well - I thought they'd be about equal. Need to see the preprint itself so we can see the actual mutations
2021-02-14 12:15 Kristian G. Andersen open

And B.1.351 is just dead dead - it's pretty scary.
2021-02-14 12:37 Robert F. Garry open

Note that all of those mutations D80A [DorA?). D215G (DouG, Jr?),R246I (RidhI?) remove a charge (aspartic acid orarginine) - if you scroll back to initial discussions of Doug you'll see references that similar D mutations havecharacterized flu mutations in the past.
2021-02-14 12:47 Edward C. Holmes

Yes, this is coming along nicely. Great work Bob. Let's try and get this sent this week if we can. It's coming along nicely.
2021-02-14 12:54 Robert F. Garry open

Will do!
2021-02-14 13:30 Andrew Rambaut open

@Kristian Andersen yeah better to seem to release them as the result of an FOI
2021-02-14 13:30 Kristian G. Andersen open

@Kristian Andersen Should I maybe release that one, redacting Mike's name? I'm kinda tempted...
2021-02-14 13:32 Edward C. Holmes open

@Kristian Andersen Let's see how this transpires. It's possible that USYD will reject the request. It's a long process.