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Slack / Private Message Drop, pp.514-515 [SLACK_000728] · slack_pm:msg:05373

Page text: p.514, p.515 · original PDF

Date
2021-02-14 12:37
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Note that all of those mutations D80A [DorA?). D215G (DouG, Jr?),R246I (RidhI?) remove a charge (aspartic acid orarginine) - if you scroll back to initial discussions of Doug you'll see references that similar D mutations havecharacterized flu mutations in the past.

In context

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  1. 2021-02-14 12:00 Kristian G. Andersen open
    And IMO - highly suggestive of lower overall antigenicity of B.1.351 - i.e., a more general mechanism of (Ab-mediated) immune evasion.
  2. 2021-02-14 12:13 Robert F. Garry open
    Kind of surprising to me -P1 takes a hit, but B.1.351 is bad. Does it suggest that the B.1.351 NTD mutations D80A[DorA?). D215G (DouG, Jr?),R246I (RidhI?) may be more problematic than EriK????
  3. 2021-02-14 12:15 Kristian G. Andersen open
    Yeah, I was really surprised by that difference as well - I thought they'd be about equal. Need to see the preprint itself so we can see the actual mutations
  4. 2021-02-14 12:15 Kristian G. Andersen open
    And B.1.351 is just dead dead - it's pretty scary.
  5. 2021-02-14 12:37 Robert F. Garry
    Note that all of those mutations D80A [DorA?). D215G (DouG, Jr?),R246I (RidhI?) remove a charge (aspartic acid orarginine) - if you scroll back to initial discussions of Doug you'll see references that similar D mutations havecharacterized flu mutations in the past.
  6. 2021-02-14 12:47 Edward C. Holmes open
    Yes, this is coming along nicely. Great work Bob. Let's try and get this sent this week if we can. It's coming along nicely.
  7. 2021-02-14 12:54 Robert F. Garry open
    Will do!
  8. 2021-02-14 13:30 Andrew Rambaut open
    @Kristian Andersen yeah better to seem to release them as the result of an FOI
  9. 2021-02-14 13:30 Kristian G. Andersen open
    @Kristian Andersen Should I maybe release that one, redacting Mike's name? I'm kinda tempted...

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