Slack / Private Message Drop — page 514

Well done @Kristian Andersen - !channel let's hit them with some hard science with the cambobat post. Eddie nearly has it cleaned up nicely... [2021-02-14 11:14:12] [Kristian Andersen] [thread - ID: 2021-02-14 11:14:12] @Eddie Holmes - do you know if this particular email will be made public as part of your FOIA? It reflects well where we stood early in our research. [shared file(s): Screen Shot 2021-02-14 at 11.12.37 AM.png] [2021-02-14 11:28:20] [Eddie Holmes] [thread - ID: 2021-02-14 11:14:12] No. The FOI request wanted emails related to the papers. As this is before the paper I didn't include it. But we could of course release it ourselves if necessary. [2021-02-14 11:40:30] [Kristian Andersen] [thread - ID: 2021-02-14 11:14:12] @Kristian Andersen Ah, okay. I'll leave this under wraps for now - but once we have the list of emails to be released, we might want to put out a few of them with some context. They'll be noticed, no doubt. [2021-02-14 11:43:00] [Eddie Holmes] [thread - ID: 2021-02-14 11:14:12] Agreed. There's a few that I can also release. [2021-02-14 11:58:37] [Kristian Andersen] Very interesting figure! [shared file(s): EuNejqhXcAUjMGC.jpeg] [2021-02-14 11:59:43] [Kristian Andersen] What's wild - two doses of Pfizer leads to greater neutralization against SARS-CoV than B.1.351 according to this figure. That's wild.\ [2021-02-14 12:00:50] [Kristian Andersen] And IMO - highly suggestive of lower overall antigenicity of B.1.351 - i.e., a more general mechanism of (Ab-mediated) immune evasion. [2021-02-14 12:13:27] [Robert Garry] Kind of surprising to me -P1 takes a hit, but B.1.351 is bad. Does it suggest that the B.1.351 NTD mutations D80A [DorA?). D215G (DouG, Jr?),R246I (RidhI?) may be more problematic than EriK???? [2021-02-14 12:15:36] [Kristian Andersen] Yeah, I was really surprised by that difference as well - I thought they'd be about equal. Need to see the preprint itself so we can see the actual mutations [2021-02-14 12:15:59] [Kristian Andersen] And B.1.351 is just dead dead - it's pretty scary. [2021-02-14 12:37:23]