COVID-19 Records

Chat message

Slack / Private Message Drop, p.514 [SLACK_000728] · slack_pm:msg:05368

Page text: p.514 · original PDF

Date
2021-02-14 11:59
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen
Topics
Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

What's wild - two doses of Pfizer leads to greater neutralization against SARS-CoV than B.1.351 according to this figure. That's wild.\

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-02-14 11:28 Edward C. Holmes open
    No. The FOI request wanted emails related to the papers. As this is before the paper I didn't include it. But we couldof course release it ourselves if necessary.
  2. 2021-02-14 11:40 Kristian G. Andersen open
    @Kristian Andersen Ah, okay. I'll leave this under wraps for now - but once we have the list of emails to be released,we might want to put out a few of them with some context. They'll be noticed, no doubt.
  3. 2021-02-14 11:43 Edward C. Holmes open
    Agreed. There's a few that I can also release.
  4. 2021-02-14 11:58 Kristian G. Andersen open
    Very interesting figure! [shared file(s): EuNejqhXcAUjMGC.jpeg]
  5. 2021-02-14 11:59 Kristian G. Andersen
    What's wild - two doses of Pfizer leads to greater neutralization against SARS-CoV than B.1.351 according to this figure. That's wild.\
  6. 2021-02-14 12:00 Kristian G. Andersen open
    And IMO - highly suggestive of lower overall antigenicity of B.1.351 - i.e., a more general mechanism of (Ab-mediated) immune evasion.
  7. 2021-02-14 12:13 Robert F. Garry open
    Kind of surprising to me -P1 takes a hit, but B.1.351 is bad. Does it suggest that the B.1.351 NTD mutations D80A[DorA?). D215G (DouG, Jr?),R246I (RidhI?) may be more problematic than EriK????
  8. 2021-02-14 12:15 Kristian G. Andersen open
    Yeah, I was really surprised by that difference as well - I thought they'd be about equal. Need to see the preprint itself so we can see the actual mutations
  9. 2021-02-14 12:15 Kristian G. Andersen open
    And B.1.351 is just dead dead - it's pretty scary.

Full conversation →