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Slack / Private Message Drop, p.399 [SLACK_000613] · slack_pm:msg:04119

Page text: p.399 · original PDF

Date
2021-01-14 15:47
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

Indeed. Not saying the theory is wrong, just that there are some loose ends. I can only imagine how Alina and ganghave reacted to this: [shared file(s): s41591-020-01205-5.pdf]

In context

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  1. 2021-01-14 14:39 Andrew Rambaut open
    Within host (and with the additional benefit of recombination) these combinations are readily obtainable.
  2. 2021-01-14 15:20 Edward C. Holmes open
    Given the low frequency of chronic infections compared to the huge number with 'normal' durations of infection, doesn't the fact that we are seeing the same sort of constellation of mutations evolve and spread 3 times independently suggest that they have a major advantage at the population level?
  3. 2021-01-14 15:46 Andrew Rambaut open
    Yes - they do. But I think they can't get there by progressive steps in sequential infections - there are troughs (wesee all of these mutations appear individually many times).
  4. 2021-01-14 15:47 Andrew Rambaut open
    So the chronic infections offer an opportunity for these to arise in combination. Chronic infections are rare as aproportion of infections but there are shed loads of infections now.
  5. 2021-01-14 15:47 Edward C. Holmes
    Indeed. Not saying the theory is wrong, just that there are some loose ends. I can only imagine how Alina and ganghave reacted to this: [shared file(s): s41591-020-01205-5.pdf]
  6. 2021-01-14 15:54 Andrew Rambaut open
    Nice piece. Angie is a true hero. I can't imagine what she must put up with (you probably can more than me, Eddie, but women get it so much worse).
  7. 2021-01-14 15:58 Edward C. Holmes open
    She's a 1000X times tougher than me. I find it very difficult and have to get off social media as much as I can. I also hate dealing with the mainstream media. She must get endless shit. No idea how she manages it.
  8. 2021-01-14 16:03 Kristian G. Andersen open
    Angie is indeed tough as nails - true hero! I *do* wonder if she has a hard time dealing with all the shit she must begetting - she _is_ moving to Canada after all. Can't blame for for leaving this dumpster fire - I'd do the same in aheartbeat if anybody up north wanted me.
  9. 2021-01-14 16:04 Edward C. Holmes open
    There's an opening at the Wuhan Institute of Virology. Labs were recently renovated and cleaned.

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