Slack / Private Message Drop — page 379

[2021-01-11 13:46:45] [Eddie Holmes] There's this as well - from Bahia: https://www.preprints.org/manuscript/202101.0132/v1 [2021-01-11 13:48:06] [Eddie Holmes] @Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy. [2021-01-11 13:51:28] [Eddie Holmes] Although I guess it also shows that these mutations are going to appear all over the place. [2021-01-11 13:51:43] [Kristian Andersen] Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some. [2021-01-11 13:52:09] [Eddie Holmes] Yes, I think you may be right. [2021-01-11 13:52:16] [Kristian Andersen] Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but it starts at 3am for me.... [2021-01-11 13:55:23] [Eddie Holmes] I'm going to have to pass because I have a very late meeting the following night that I'll need to rested for. Looking forward to a debrief from Andrew! [2021-01-11 13:57:04] [Andrew Rambaut] We have 5 cases of Erik on top of the B117 but they are spontaneous and I doubt driven by antigenic evasion. [2021-01-11 13:57:20] [Eddie Holmes] Bum. [2021-01-11 13:58:04] [Andrew Rambaut] I can't make the WHO thing but they have Tulio, Trevor and Marion on the evolution panel. I couldn't do it so I got Oli instead. [2021-01-11 13:58:49] [Andrew Rambaut] Really struggling to work out what is going on. [2021-01-11 13:59:09] [Andrew Rambaut] It seems like all of these lineages are converging to the same set of mutations [2021-01-11 13:59:14] [Eddie Holmes]