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Slack / Private Message Drop, p.379 [SLACK_000593] · slack_pm:msg:03939

Date: 2021-01-11 13:48
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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@Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy.

In context

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2021-01-11 13:05 Andrew Rambaut open

Remember that cluster possibly from Uganda with 681R and 613H? Now spreading in UK and has some with 484K. What is happening?
2021-01-11 13:06 Kristian G. Andersen open

You tell me - you're the expert
2021-01-11 13:08 Kristian G. Andersen open

And I'd add - probably reinfections, possibly asymptomatic driving E484K.
2021-01-11 13:46 Edward C. Holmes open

There's this as well - from Bahia: https://www.preprints.org/manuscript/202101.0132/v1
2021-01-11 13:48 Edward C. Holmes

@Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy.
2021-01-11 13:51 Edward C. Holmes open

Although I guess it also shows that these mutations are going to appear all over the place.
2021-01-11 13:51 Kristian G. Andersen open

Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some.
2021-01-11 13:52 Edward C. Holmes open

Yes, I think you may be right.
2021-01-11 13:52 Kristian G. Andersen open

Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but itstarts at 3am for me....

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