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Slack / Private Message Drop, pp.379-380 [SLACK_000593] · slack_pm:msg:03950

Page text: p.379, p.380 · original PDF

Date: 2021-01-11 13:59
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-11 13:57 Edward C. Holmes open

Bum.
2021-01-11 13:58 Andrew Rambaut open

I can't make the WHO thing but they have Tulio, Trevor and Marion on the evolution panel. I couldn't do it so I got Oli instead.
2021-01-11 13:58 Andrew Rambaut open

Really struggling to work out what is going on.
2021-01-11 13:59 Andrew Rambaut open

It seems like all of these lineages are converging to the same set of mutations
2021-01-11 13:59 Edward C. Holmes

I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours.
2021-01-11 13:59 Andrew Rambaut open

Oli will keep him right
2021-01-11 13:59 Robert F. Garry open

https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase Itrial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna isprotecting it's newly hatched golden goose.
2021-01-11 13:59 Edward C. Holmes open

:bomb:
2021-01-11 14:07 Robert F. Garry open

"It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed thetrimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasiswith Doug.

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