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Slack / Private Message Drop, p.379 [SLACK_000593] · slack_pm:msg:03943

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Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but itstarts at 3am for me....

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2021-01-11 13:48 Edward C. Holmes open

@Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy.
2021-01-11 13:51 Edward C. Holmes open

Although I guess it also shows that these mutations are going to appear all over the place.
2021-01-11 13:51 Kristian G. Andersen open

Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some.
2021-01-11 13:52 Edward C. Holmes open

Yes, I think you may be right.
2021-01-11 13:52 Kristian G. Andersen

Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but itstarts at 3am for me....
2021-01-11 13:55 Edward C. Holmes open

I'm going to have to pass because I have a very late meeting the following night that I'll need to rested for. Looking forward to a debrief from Andrew!
2021-01-11 13:57 Andrew Rambaut open

We have 5 cases of Erik on top of the B117 but they are spontaneous and I doubt driven by antigenic evasion.
2021-01-11 13:57 Edward C. Holmes open

Bum.
2021-01-11 13:58 Andrew Rambaut open

I can't make the WHO thing but they have Tulio, Trevor and Marion on the evolution panel. I couldn't do it so I got Oli instead.