Slack / Private Message Drop — page 380

I hope Tulio gets talking combining classification schemes - that will make a fun 7 hours. [2021-01-11 13:59:32] [Andrew Rambaut] Oli will keep him right [2021-01-11 13:59:49] [Robert Garry] https://www.fox10phoenix.com/news/fda-to-weigh-half-dosing-moderna-covid-19-vaccines-operation-warp-speed-of ficial-says "These are all reasonable questions to consider and evaluate in clinical trials," the FDA said in a statement on Monday." I agree that the UK dosing strategy is wrong - half dosing makes much more sense with both the prime and the boast. The half and third dosing was already considered in a clinical trial - Moderna's Phase I trial. Two doses of 10 ug gave essentially the same neut and binding as two doses of 30 ug dose. One dose of 100 was terrible and caused al ot more adverse reactions so tjhey stopped it. Hate to be cynical, but I think Moderna is protecting it's newly hatched golden goose. [2021-01-11 13:59:50] [Eddie Holmes] :bomb: [2021-01-11 14:07:42] [Robert Garry] "It seems like all of these lineages are converging to the same set of mutations." Agree - Spike is covered with glycan - there are only a few places where antibodies can slip in - Eeek and the NTD mutations are in those spots. Once this virus got a furin cleavage site it opened up the possibility for Doug and its 613 twins to destabilzed the trimers so you could get surface entry. The furin cleavage site is continuing to optimize itself possibly in epistasis with Doug. [2021-01-11 14:41:22] [Andrew Rambaut] The Japanese/Manaus cluster has the same nsp6 deletion that the UK and South African lineages have [2021-01-11 14:43:37] [Eddie Holmes] Wowser. That's not chance. [2021-01-11 14:51:59] [Robert Garry] Places where the polymerase has tendency to slip and skip? [2021-01-11 15:05:54] [Andrew Rambaut] The Manaus/Japanese cluster has a very long branch (too long) - possibly another 'chronic infection' event? [2021-01-11 15:06:02] [Kristian Andersen] What does nsp6 do again? Is it possible it's directly interacting with the spike protein to determine e.g., binding? [2021-01-11 15:06:14] [Andrew Rambaut] ```ORF1ab synT733C F681L I760T synC2749T S1188L K1795Q