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Slack / Private Message Drop, p.379 [SLACK_000593] · slack_pm:msg:03941

Page text: p.379 · original PDF

Date
2021-01-11 13:51
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some.

In context

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  1. 2021-01-11 13:08 Kristian G. Andersen open
    And I'd add - probably reinfections, possibly asymptomatic driving E484K.
  2. 2021-01-11 13:46 Edward C. Holmes open
    There's this as well - from Bahia: https://www.preprints.org/manuscript/202101.0132/v1
  3. 2021-01-11 13:48 Edward C. Holmes open
    @Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy.
  4. 2021-01-11 13:51 Edward C. Holmes open
    Although I guess it also shows that these mutations are going to appear all over the place.
  5. 2021-01-11 13:51 Kristian G. Andersen
    Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some.
  6. 2021-01-11 13:52 Edward C. Holmes open
    Yes, I think you may be right.
  7. 2021-01-11 13:52 Kristian G. Andersen open
    Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but itstarts at 3am for me....
  8. 2021-01-11 13:55 Edward C. Holmes open
    I'm going to have to pass because I have a very late meeting the following night that I'll need to rested for. Looking forward to a debrief from Andrew!
  9. 2021-01-11 13:57 Andrew Rambaut open
    We have 5 cases of Erik on top of the B117 but they are spontaneous and I doubt driven by antigenic evasion.

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