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Slack / Private Message Drop, p.379 [SLACK_000593] · slack_pm:msg:03940

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Although I guess it also shows that these mutations are going to appear all over the place.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-11 13:06 Kristian G. Andersen open

You tell me - you're the expert
2021-01-11 13:08 Kristian G. Andersen open

And I'd add - probably reinfections, possibly asymptomatic driving E484K.
2021-01-11 13:46 Edward C. Holmes open

There's this as well - from Bahia: https://www.preprints.org/manuscript/202101.0132/v1
2021-01-11 13:48 Edward C. Holmes open

@Andrew Rambaut I have to say that if immune selection has driven the appearance of Erik in Amazonia that does make me a bit more worried about the UK dosing strategy.
2021-01-11 13:51 Edward C. Holmes

Although I guess it also shows that these mutations are going to appear all over the place.
2021-01-11 13:51 Kristian G. Andersen open

Great... I guess that's probably separate to the study on Virological. I'm leaning towards E484K being able to escape immunity by now - maybe not in all cases, but at least in some.
2021-01-11 13:52 Edward C. Holmes open

Yes, I think you may be right.
2021-01-11 13:52 Kristian G. Andersen open

Are any of you going to be on the WHO call tomorrow focused on this mutation stuff? Wondering if I should go, but itstarts at 3am for me....
2021-01-11 13:55 Edward C. Holmes open

I'm going to have to pass because I have a very late meeting the following night that I'll need to rested for. Looking forward to a debrief from Andrew!