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Slack / Private Message Drop, p.1026 [SLACK_001240] · slack_pm:msg:10726

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Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know....

In context

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2021-11-24 08:48 Robert F. Garry open

I've think that the enzymes that do the cleavage at R/S also probably benefit by having a "landing pad."
2021-11-24 08:50 Andrew Rambaut open

So if you were going to pick a virus from amongst your large bank of samples in which to try popping a FCS insertion you would pick out one with QTQT?
2021-11-24 08:52 Robert F. Garry open

Not without having all the knowledge in hindsight.
2021-11-24 08:52 Andrew Rambaut open

Fair enough. I won't tweet that then.
2021-11-24 08:52 Robert F. Garry

Same argument with the O-linked glycans - without having SC2 as the guidepost - you would not know....
2021-11-24 08:53 Robert F. Garry open

Good - that would just encourage the Leakers...
2021-11-24 08:54 Kristian G. Andersen open

Yeah, very clearly not a conscious choice - just nature doing it's thing. All it took was a virus with a landing site and then stuff comes and goes around that site all the time - just had to be the right sequence that popped in.
2021-11-24 08:55 Robert F. Garry open

Yup - nature - we get to see the brilliance but only afterwards.
2021-11-24 09:02 Kristian G. Andersen open

Some alignments with these sequences combined with relevant SARSr-CoVs - just FYI. [shared file(s): 2021.11.24_alignment_spike_nt.geneious, 2021.11.24_alignment_spike_aa.geneious, 2021.11.24_alignment_spike_aa_minimal_annotated.geneious]